2. Academic Validation
  3. Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea

Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea

  • J Nat Prod. 2021 Sep 24;84(9):2600-2605. doi: 10.1021/acs.jnatprod.1c00365.
Marco Masi 1,  Roberta Di Lecce 1,  Giulia Marsico 2,  Benedetto Teodoro Linaldeddu 3,  Lucia Maddau 4,  Stefano Superchi 2,  Antonio Evidente 1
Affiliations

Affiliations

  • 1 Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte Sant'Angelo, Via Cintia 4, 80126 Napoli, Italy.
  • 2 Dipartimento di Scienze, Università della Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
  • 3 Dipartimento Territorio e Sistemi Agro-Forestali, Università di Padova, Viale dell'Università 16, 35020 Legnaro, Italy.
  • 4 Dipartimento di Agraria, Sezione di Patologia Vegetale ed Entomologia, Università degli Studi di Sassari, Viale Italia 39, 07100 Sassari, Italy.
PMID: 34469140 DOI: 10.1021/acs.jnatprod.1c00365
Abstract

Two new bioactive trisubstituted furanones, named pinofuranoxins A and B (1 and 2), were isolated from Diplodia sapinea, a worldwide conifer pathogen causing severe disease. Pinofuranoxins A and B were characterized essentially by NMR and HRESIMS spectra, and their relative and absolute configurations were assigned by NOESY experiments and computational analyses of electronic circular dichroism spectra. They induced necrotic lesions on Hedera helix L., Phaseolus vulgaris L., and Quercus ilex L. Compound 1 completely inhibited the growth of Athelia rolfsii and Phytophthora cambivora, while 2 showed antioomycetes activity against P. cambivora. In the Artemia salina assay both toxins showed activity inducing larval mortality.

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