2. Academic Validation
  3. Isolation and biological activity of azocine and azocane alkaloids

Isolation and biological activity of azocine and azocane alkaloids

  • Bioorg Med Chem. 2022 Jan 15;54:116560. doi: 10.1016/j.bmc.2021.116560.
Stephanie Lee 1,  Jonathan Sperry 2
Affiliations

Affiliations

  • 1 School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand.
  • 2 School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand. Electronic address: [email protected].
PMID: 34923389 DOI: 10.1016/j.bmc.2021.116560
Abstract

Thousands of known Alkaloids contain a nitrogen (N) heterocycle. While five-, six- and seven-membered N-heterocycles (ie: pyrroles, imidazoles, indoles, pyridines and azepines and their saturated variants) are common, those with an eight-membered N-heterocycle are comparatively rare. This review discusses the structure and bioactivity of Alkaloids that contain an azocine (or saturated azocane) ring, and the array of sources whence they originate.

Keywords

Alkaloid; Azocane; Azocine; Natural product.

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