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  2. Adhesive Ergothioneine Hyaluronate Gel Protects against Radiation Gastroenteritis by Alleviating Apoptosis, Inflammation, and Gut Microbiota Dysbiosis

Adhesive Ergothioneine Hyaluronate Gel Protects against Radiation Gastroenteritis by Alleviating Apoptosis, Inflammation, and Gut Microbiota Dysbiosis

  • ACS Appl Mater Interfaces. 2023 Apr 13. doi: 10.1021/acsami.2c23142.
Yaping Liu 1 2 Chengyan Wang 2 Ruixue Liu 2 Maoru Zhao 2 Xuefeng Ding 2 Tingjun Zhang 2 Rendong He 2 Shuang Zhu 2 Xinghua Dong 2 Jiani Xie 2 3 Zhanjun Gu 2 4 Yuliang Zhao 2 4
Affiliations

Affiliations

  • 1 The First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, Anhui, China.
  • 2 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100049, China.
  • 3 China School of Food and Biological Engineering, Chengdu University, Chengdu 610106, Sichuan, China.
  • 4 College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
Abstract

Radiation gastroenteritis represents one of the most prevalent and hazardous complications of abdominopelvic radiotherapy, which not only severely reduces patients' life quality but also restricts radiotherapy efficacy. However, there is currently no clinically available oral radioprotector for this threatening disease due to its complex pathogenesis and the harsh gastrointestinal environment. To this end, this study developed a facile but effective oral radioprotector, ergothioneine hyaluronate (EGT@HA) gel, protecting against radiation gastroenteritis by synergistically regulating oxidative stress, inflammation, and gut microbiota. In vitro and cellular experiments verified the chemical stability and free radical scavenging ability of EGT and its favorable cellular radioprotective efficacy by inhibiting intracellular reactive oxidative species (ROS) generation, DNA damage, mitochondrial damage, and Apoptosis. At the in vivo level, EGT@HA with prolonged gastrointestinal residence mitigated radiation-induced gastrointestinal tissue injury, Apoptosis, neutrophil infiltration, and gut flora dysbiosis. For the first time, this work investigated the protective effects of EGT@HA gel on radiation gastroenteritis, which not only hastens the advancement of the novel gastrointestinal radioprotector but also provides a valuable gastrointestinal radioprotection paradigm by synergistically modulating oxidative stress, inflammation, and gut microbiota disturbance.

Keywords

bioadhesive gel; ergothioneine; gastrointestinal radioprotection; gut microbiota; hyaluronate; radiation gastroenteritis.

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