2. Academic Validation
  3. STING-IFN-I pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats

STING-IFN-I pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats

  • Inflamm Res. 2023 Jul 11. doi: 10.1007/s00011-023-01764-6.
Lulin Ma # 1 2,  Daling Deng # 1 2,  Tianhao Zhang 1 2,  Wenjing Zhao 1 2,  Chengxi Liu 3 2,  Shiqian Huang 1 2,  Feng Xu 1 2,  Yafeng Wang 1 2,  Shuai Zhao 2 4,  Yuanyuan Ding 1 2,  Yan Huang 2 5,  Kaixin Wang 1 2,  Yanyan Zhang 1 2,  Xinxin Yang 1 2,  Song Cao 2 4,  Xiangdong Chen 6 7
Affiliations

Affiliations

  • 1 Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • 2 Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
  • 3 Department of Anesthesiology, The Second Affiliated Hospital of University of South China, Hengyang, China.
  • 4 Department of Pain Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
  • 5 Department of Anesthesiology, The First People's Hospital of Jiangxia District, Wuhan, China.
  • 6 Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. [email protected].
  • 7 Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. [email protected].
  • # Contributed equally.
PMID: 37433890 DOI: 10.1007/s00011-023-01764-6
Abstract

Background: The purpose of this study was to study the effect of STING-IFN-I pathway on incision induced postoperative pain in rats and its possible mechanisms.

Methods: The pain thresholds were evaluated by measuring the mechanical withdrawal threshold and the thermal withdrawal latency. The satellite glial cell and macrophage of DRG were analyzed. The expression of STING, IFN-a, P-P65, iNOS, TNF-α, IL-1β and IL-6 in DRG was evaluated.

Results: The activation of STING-IFN-I pathway can reduce the mechanical hyperalgesia, thermal hyperalgesia, down-regulate the expression of P-P65, iNOS, TNF-α, IL-1β and IL-6, and inhibit the activation of satellite glial cell and macrophage in DRG.

Conclusions: The activation of STING-IFN-I pathway can alleviate incision induced acute postoperative pain by inhibiting the activation of satellite glial cell and macrophage, which reducing the corresponding neuroinflammation in DRG.

Keywords

Acute postoperative pain; Macrophage; Neuroinflammation; STING-IFN-I; Satellite glial cell.

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