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  3. A double-gain theranostic nanoplatform based on self-supplying H2O2 nanocomposites for synergistic chemodynamic/gas therapy

A double-gain theranostic nanoplatform based on self-supplying H2O2 nanocomposites for synergistic chemodynamic/gas therapy

  • J Colloid Interface Sci. 2023 Oct 19;654(Pt A):774-784. doi: 10.1016/j.jcis.2023.10.092.
Li Wang 1,  Kun Ge 2,  Jiaqi Duan 1,  Xiaomeng Du 1,  Guoqiang Zhou 3,  Lili Ma 1,  Shutao Gao 4,  Jinchao Zhang 5
Affiliations

Affiliations

  • 1 Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Material Science, Hebei University, Baoding 071002, China.
  • 2 Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Material Science, Hebei University, Baoding 071002, China. Electronic address: [email protected].
  • 3 Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Material Science, Hebei University, Baoding 071002, China; College of Basic Medical Science, Hebei University, Baoding 071000, China.
  • 4 College of Science, Hebei Agricultural University, Baoding 071002, China. Electronic address: [email protected].
  • 5 Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Material Science, Hebei University, Baoding 071002, China. Electronic address: [email protected].
PMID: 37866049 DOI: 10.1016/j.jcis.2023.10.092
Abstract

Chemodynamic therapy (CDT) based on hydroxyl radicals (•OH) to suppress tumor cells is a promising strategy due to its efficacy and safety. Nevertheless, in tumor cells, CDT still faces challenges such as insufficient •OH and weak killing effect of tumor cells under physiological conditions due to inadequate amounts of endogenous hydrogen peroxide (H2O2) and heightened glutathione expression. These challenges limit the therapeutic potential of CDT. To improve the effects of CDT, combination treatment strategies have been developed. Here, we report a rationally designed nanocomposite (CaO2@Cu-LA) with self-supplying H2O2 ability from calcium peroxide, and nitric oxide (NO) generation ability from l-arginine. NO molecules not only exhibit a strong killing effect, but also have the potential to transfer into the more cytotoxic substance peroxynitrite anion by reacting with Reactive Oxygen Species. The results showed that CaO2@Cu-LA could significantly suppress tumor growth by increasing •OH radicals and NO molecules. Taken together, the strategy developed here provides a good application foreground to yield a remarkable synergistic antitumor effect of CDT and NO gas therapy.

Keywords

Calcium peroxide; Chemodynamic therapy; Gas therapy; Nitric oxide; Synergistic antitumor therapy.

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