2. Academic Validation
  3. Inhibitory activity of soyasaponin II on virus replication in vitro

Inhibitory activity of soyasaponin II on virus replication in vitro

  • Planta Med. 1997 Apr;63(2):102-5. doi: 10.1055/s-2006-957622.
K Hayashi 1,  H Hayashi,  N Hiraoka,  Y Ikeshiro
Affiliations

Affiliation

  • 1 Department of Virology, Toyama Medical and Pharmaceutical University, Japan.
PMID: 9140220 DOI: 10.1055/s-2006-957622
Abstract

The Antiviral activities of two saponins, soyasaponin I and II, isolated from soybean (Glycine max Merrill) were studied in vitro against herpes simplex virus type 1 (HSV-1). Soyasaponin II was more potent than soyasaponin I as shown by reduction of HSV-1 production. Soyasaponin II was also found to inhibit the replication of human cytomegalovirus, Influenza Virus, and human immunodeficiency virus type 1. The action was not due to inhibition of virus penetration and protein synthesis, but might involve a virucidal effect. When acyclovir and soyasaponin II were evaluated in combination for anti-HSV-1 activity, additive Antiviral effects were observed for this virus.

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