2. Academic Validation
  3. Tripeptide growth hormone secretagogues

Tripeptide growth hormone secretagogues

  • Bioorg Med Chem Lett. 1998 Apr 7;8(7):759-64. doi: 10.1016/s0960-894x(98)00103-6.
L Yang 1,  G Morriello,  Y Pan,  R P Nargund,  K Barakat,  K Prendergast,  K Cheng,  W W Chan,  R G Smith,  A A Patchett
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, and Biochemistry & Physiology, Merck Research Laboratories, Rahway, NJ 07065, USA.
PMID: 9871537 DOI: 10.1016/s0960-894x(98)00103-6
Abstract

A series of C-terminus capped dipeptides and tripeptides was synthesized as growth hormone (GH) secretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa-hepta-GH releasing Peptides can be mimicked at the tripeptide level.

Figures
Products