MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D

Name: MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D
Brand: MedChemExpress
SKU: HY-145488
Rating: 4.5 (1 reviews)

Cat. No.: HY-145488 Purity: 98.92%: FAQs
Data Sheet SDS COA Handling Instructions

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MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D Chemical Structure

CAS No. : 2222445-87-4

Size	Price	Stock	Quantity
1 mg	USD 690	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1680	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2700	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 5500	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)^[1].

IC₅₀ & Target

Cleavable Linker

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

859.36

Formula

C₄₄H₅₁ClN₆O₁₀

CAS No.

2222445-87-4

Appearance

Solid

Color

White to light yellow

SMILES

ClC[C@H]1C2=C(C=C(C3=CC=CC(C)=C32)OC(N(CCOCCO)CCN(C)C(OC(C)(C)C)=O)=O)N(C1)C(C4=CN(C=C(C=C5)NC(C6=CC=C(C=C6)OCOC)=O)C5=N4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (58.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1637 mL	5.8183 mL	11.6366 mL
5 mM	0.2327 mL	1.1637 mL	2.3273 mL
10 mM	0.1164 mL	0.5818 mL	1.1637 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.92%

Select Batch:

Data Sheet (274 KB) SDS (394 KB)

COA (256 KB) HNMR (366 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1637 mL	5.8183 mL	11.6366 mL	29.0914 mL
	5 mM	0.2327 mL	1.1637 mL	2.3273 mL	5.8183 mL
	10 mM	0.1164 mL	0.5818 mL	1.1637 mL	2.9091 mL
	15 mM	0.0776 mL	0.3879 mL	0.7758 mL	1.9394 mL
	20 mM	0.0582 mL	0.2909 mL	0.5818 mL	1.4546 mL
	25 mM	0.0465 mL	0.2327 mL	0.4655 mL	1.1637 mL
	30 mM	0.0388 mL	0.1939 mL	0.3879 mL	0.9697 mL
	40 mM	0.0291 mL	0.1455 mL	0.2909 mL	0.7273 mL
	50 mM	0.0233 mL	0.1164 mL	0.2327 mL	0.5818 mL