2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. mGluR5 antagonist-1

mGluR5 antagonist-1 (compound 10) is a high-affinity mGluR5 antagonist, with an IC50 value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect.

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mGluR5 antagonist-1 Chemical Structure

mGluR5 antagonist-1 Chemical Structure

CAS No. : 2761424-76-2

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Description

mGluR5 antagonist-1 (compound 10) is a high-affinity mGluR5 antagonist, with an IC50 value of 11.5 nM. mGluR5 antagonist-1 has anti-depressant effect[1].

Molecular Weight

382.41

Formula

C23H18N4O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CN1C2=NC=NC(C#CC3=CC=CC=C3)=C2C=C1C(NC4=CC=C(OC)C=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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mGluR5 antagonist-1 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mGluR5 antagonist-12761424-76-2mGluRMetabotropic glutamate receptorsmGluR5 antagonistInhibitorinhibitorinhibit

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