2. Autophagy Neuronal Signaling
  3. PINK1/Parkin
  4. MitoBloCK-11

MitoBloCK-11 is a new small molecule with a protein-binding target, Seo1. MitoBloCK-11 plays an important role in the delivery of PINK1 pathway. MitoBloCK-11 can be used in the study of autosomal recessive Parkinson's disease.

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MitoBloCK-11 Chemical Structure

MitoBloCK-11 Chemical Structure

CAS No. : 413606-16-3

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1 mg USD 316 In-stock
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MitoBloCK-11 Related Antibodies

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Description

MitoBloCK-11 is a new small molecule with a protein-binding target, Seo1. MitoBloCK-11 plays an important role in the delivery of PINK1 pathway. MitoBloCK-11 can be used in the study of autosomal recessive Parkinson's disease[1].

Molecular Weight

434.26

Formula

C17H12BrN3O4S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N/N=C/C1=CC=C([N+]([O-])=O)S1)COC2=C3C=CC=CC3=C(Br)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (287.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3028 mL 11.5138 mL 23.0277 mL
5 mM 0.4606 mL 2.3028 mL 4.6055 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3028 mL 11.5138 mL 23.0277 mL 57.5692 mL
5 mM 0.4606 mL 2.3028 mL 4.6055 mL 11.5138 mL
10 mM 0.2303 mL 1.1514 mL 2.3028 mL 5.7569 mL
15 mM 0.1535 mL 0.7676 mL 1.5352 mL 3.8379 mL
20 mM 0.1151 mL 0.5757 mL 1.1514 mL 2.8785 mL
25 mM 0.0921 mL 0.4606 mL 0.9211 mL 2.3028 mL
30 mM 0.0768 mL 0.3838 mL 0.7676 mL 1.9190 mL
40 mM 0.0576 mL 0.2878 mL 0.5757 mL 1.4392 mL
50 mM 0.0461 mL 0.2303 mL 0.4606 mL 1.1514 mL
60 mM 0.0384 mL 0.1919 mL 0.3838 mL 0.9595 mL
80 mM 0.0288 mL 0.1439 mL 0.2878 mL 0.7196 mL
100 mM 0.0230 mL 0.1151 mL 0.2303 mL 0.5757 mL
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MitoBloCK-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MitoBloCK-11413606-16-3MitoBloCK11MitoBloCK 11PINK1/ParkinmitochondriaParkinson’s diseaseHeLa cellsInhibitorinhibitorinhibit

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