1. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  2. 5-HT Receptor Cytochrome P450 Potassium Channel
  3. Mosapride

Mosapride citrate is an orally active gastroenterokinetic compound. Mosapride citrate is a 5HT4agonist. Mosapride citrate is a CYP inducer. Mosapride citrate has a concentration-dependent inhibitory effect on Kv4.3, and its IC50 value is 15.2 μM. Mosapride citrate can be used in the study of gastrointestinal diseases.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Mosapride citrate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Mosapride Chemical Structure

Mosapride Chemical Structure

CAS No. : 112885-41-3

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Description

Mosapride citrate is an orally active gastroenterokinetic compound. Mosapride citrate is a 5HT4agonist. Mosapride citrate is a CYP inducer. Mosapride citrate has a concentration-dependent inhibitory effect on Kv4.3, and its IC50 value is 15.2 μM. Mosapride citrate can be used in the study of gastrointestinal diseases[1][2][3][4][5][6][7].

IC50 & Target

5-HT4 Receptor

 

In Vitro

Mosapride citrate (1-100 nM) significantly increases the average amplitude of proximal and distal colon contraction, and shortens the transport time of proximal and distal colon in guinea-pig[3].
Mosapride citrate (869 ng/mL, 48 h) increases the induction ability of Cytochrome P450 (CYP1A2, 2B6 and 3A4) in human hepatocytes (HMC424, 478 and 493)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mosapride citrate (0.3-3 mg/kg or 30 mg/kg p.o) promotes gastric empting rats in a dose-dependent manner. Gastric emptying was significantly inhibited when the dose was 30 mg/kg[5].
Mosapride citrate (0.5 mg/kg p.o) can relieve NSAIDS induced ulcer by activating 5-HT4 receptor in rats[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NSAID-induced experimental ulcer model
Dosage: 0.25, 0.5 , 0.75 mg/kg
Administration: p.o
Result: Inhibited the mucosal damage.
Clinical Trial
Molecular Weight

421.89

Formula

C21H25ClFN3O3

CAS No.
SMILES

O=C(NCC1CN(CC2=CC=C(F)C=C2)CCO1)C3=CC(Cl)=C(N)C=C3OCC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Mosapride
Cat. No.:
HY-B0189
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