2. Anti-infection
  3. Bacterial
  4. MtInhA-IN-1

MtInhA-IN-1 is a selective and orally active Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) inhibitor with an IC50 of 0.23 μM. MtInhA-IN-1 potently against M. tuberculosis H37Rv strain with a MIC value of 0.4 μM.

For research use only. We do not sell to patients.

MtInhA-IN-1 Chemical Structure

MtInhA-IN-1 Chemical Structure

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MtInhA-IN-1 Related Antibodies

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Description

MtInhA-IN-1 is a selective and orally active Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) inhibitor with an IC50 of 0.23 μM. MtInhA-IN-1 potently against M. tuberculosis H37Rv strain with a MIC value of 0.4 μM[1].

IC50 & Target

IC50: 0.23 μM (Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA))[1]
MIC: 0.4 μM (M. tuberculosis H37Rv strain), 0.1 μM (M. tuberculosis strains PT2), 0.2 μM (M. tuberculosis strains PT12), and 0.1 μM (M. tuberculosis strains PT20)[1]
In Vitro

MtInhA-IN-1 (compound 19k) shows inhibitory activity against a panel of multidrug-resistant M. tuberculosis strains, M. tuberculosis strains PT2, PT12, and PT20. The MIC values of 0.1 μM, 0.2 μM, and 0.1 μM for PT2, PT12, and PT20, respectively. In addition, MtInhA-IN-1 has low cytotoxicity against HepG2 and Vero cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MtInhA-IN-1 Related Antibodies
In Vivo

MtInhA-IN-1 (compound 19k; 300-450 μM/kg; p.o; daily; for 14 days) shows bacteriostatic effect in a murine model of tuberculosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: M. tuberculosis-infected mice [1]
Dosage: 300 μM/kg and 450 μM/kg
Administration: Oral administration; daily; for 14 days
Result: Reduced the growth of bacilli in the lungs of mice.
Molecular Weight

396.32

Formula

C21H22BrN3
SMILES

CC1=NC2=C(C(NC3=CC=C(C=C3)N4CCCCC4)=C1)C=C(C=C2)Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MtInhA-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MtInhA-IN-1BacterialMtInhA inhibitorMycobacterium tuberculosisorally active4-aminoquinolinesInhibitorinhibitorinhibit

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