1. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  2. EGFR
  3. Mutated EGFR-IN-1

Mutated EGFR-IN-1  (Synonyms: Osimertinib analog)

Cat. No.: HY-78869 Purity: 99.84%
COA Handling Instructions

Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant.

For research use only. We do not sell to patients.

Mutated EGFR-IN-1 Chemical Structure

Mutated EGFR-IN-1 Chemical Structure

CAS No. : 1421372-66-8

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Solid
5 mg USD 32 In-stock
10 mg USD 50 In-stock
50 mg USD 75 In-stock
100 mg USD 100 In-stock
500 mg USD 250 In-stock
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Description

Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant and T790M resistance mutant. IC50 value: Target: Mutated EGFR inhibitor More information can be found in Patent WO 2013014448 A1.2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer.

IC50 & Target[1]

EGFRL858R

 

EGFRExon 19 deletion/T790M

 

EGFRT790M

 

Molecular Weight

445.56

Formula

C25H31N7O

CAS No.
Appearance

Solid

SMILES

NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 75 mg/mL (168.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2444 mL 11.2218 mL 22.4437 mL
5 mM 0.4489 mL 2.2444 mL 4.4887 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.84%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2444 mL 11.2218 mL 22.4437 mL 56.1092 mL
5 mM 0.4489 mL 2.2444 mL 4.4887 mL 11.2218 mL
10 mM 0.2244 mL 1.1222 mL 2.2444 mL 5.6109 mL
15 mM 0.1496 mL 0.7481 mL 1.4962 mL 3.7406 mL
20 mM 0.1122 mL 0.5611 mL 1.1222 mL 2.8055 mL
25 mM 0.0898 mL 0.4489 mL 0.8977 mL 2.2444 mL
30 mM 0.0748 mL 0.3741 mL 0.7481 mL 1.8703 mL
40 mM 0.0561 mL 0.2805 mL 0.5611 mL 1.4027 mL
50 mM 0.0449 mL 0.2244 mL 0.4489 mL 1.1222 mL
60 mM 0.0374 mL 0.1870 mL 0.3741 mL 0.9352 mL
80 mM 0.0281 mL 0.1403 mL 0.2805 mL 0.7014 mL
100 mM 0.0224 mL 0.1122 mL 0.2244 mL 0.5611 mL
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Mutated EGFR-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Mutated EGFR-IN-1
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