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  5. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA  (Synonyms: MOG (35-55) (TFA))

Cat. No.: HY-P1240A Purity: 99.90%
COA Handling Instructions

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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) TFA is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA has encephalitogenic activity and induces T cell proliferative. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA induces Th1 cytokine response as well as relatively high levels of IgG antibodies. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA produces a relapsing-remitting neurological disease with extensive plaque-like demyelination.

For research use only. We do not sell to patients.

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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA Chemical Structure

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA Chemical Structure

Size Price Stock Quantity
1 mg USD 70 In-stock
5 mg USD 190 In-stock
10 mg USD 305 In-stock
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100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 4 publication(s) in Google Scholar

Other Forms of Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA:

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA Related Antibodies

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  • Purity & Documentation

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Description

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) TFA is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA has encephalitogenic activity and induces T cell proliferative. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA induces Th1 cytokine response as well as relatively high levels of IgG antibodies. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA produces a relapsing-remitting neurological disease with extensive plaque-like demyelination[1][2][3].

In Vitro

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55); 0-50 μg/mL; 72 h; lymph nodes cells) TFA induces T?cell proliferative and secretes Th1 cytokines including IFN-γ, TNF-α, IL-10, IL-4 and IL-5. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA increases the level of IgG[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA Related Antibodies
In Vivo

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA can be used in animal modeling to construct mouse encephalomyelitis model.

Myelin Oligodendrocyte Glycoprotein Peptide (35-55) TFA (MOG (35-55); 200 μg (0.2 mL); i.p.; once, for 38 d) has encephalitogenic activity in HLA-DR2 (DRB1*1501) mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HLA-DR2 (DRB1*1501) mice[1]
Dosage: 200 μg (0.2 mL)
Administration: Intraperitoneal injection; once, for 38 days
Result: Resulted in paralysis of both hind and forelimbs.
Molecular Weight

2695.97

Formula

C120H178F3N35O31S
Appearance

Solid

Color

White to off-white

Sequence

Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys
Sequence Shortening

MEVGWYRSPFSRVVHLYRNGK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (18.55 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3709 mL 1.8546 mL 3.7092 mL
5 mM 0.0742 mL 0.3709 mL 0.7418 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (37.09 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.90%

COA (243 KB) LCMS (267 KB) Elemental Analysis Report (101 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.3709 mL 1.8546 mL 3.7092 mL 9.2731 mL
5 mM 0.0742 mL 0.3709 mL 0.7418 mL 1.8546 mL
10 mM 0.0371 mL 0.1855 mL 0.3709 mL 0.9273 mL
15 mM 0.0247 mL 0.1236 mL 0.2473 mL 0.6182 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, ratMOG (35-55) (TFA)OthersautoantigenicdemyelinatingplaqueautoimmunityInhibitorinhibitorinhibit

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