N-Acetyl lysyltyrosylcysteine amide

Name: N-Acetyl lysyltyrosylcysteine amide
Brand: MedChemExpress
SKU: HY-125039
Rating: 4.5 (2 reviews)

Cat. No.: HY-125039 Purity: 99.57%: FAQs
Data Sheet SDS COA Handling Instructions

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N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo. N-Acetyl lysyltyrosylcysteine amide reduces neuronal damage and preserves brain tissue and neurological function in the stroked brain. N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL oxidation.

For research use only. We do not sell to patients.

N-Acetyl lysyltyrosylcysteine amide Chemical Structure

CAS No. : 1287585-40-3

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 250	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 250	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 225	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 2 publication(s) in Google Scholar

2 Publications Citing Use of MCE N-Acetyl lysyltyrosylcysteine amide

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

N-Acetyl lysyltyrosylcysteine amide (KYC) significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice^[1].
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice^[1].
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-10 weeks old C57BL/6J mice (middle cerebral artery occlusion (MCAO) mode)^[1]
Dosage:	10 mg/kg
Administration:	I.p.; daily for 3-7 days
Result:	Significantly reduced neurological deficit and brain infarct size in mice subjected to MCAO.

Molecular Weight

453.56

Formula

C₂₀H₃₁N₅O₅S

CAS No.

1287585-40-3

Appearance

Solid

Color

White to off-white

SMILES

SC[C@@H](C(N)=O)NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CCCCN)NC(C)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (275.60 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2048 mL	11.0239 mL	22.0478 mL
5 mM	0.4410 mL	2.2048 mL	4.4096 mL
10 mM	0.2205 mL	1.1024 mL	2.2048 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.81%

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Data Sheet (276 KB) SDS (251 KB)

COA (251 KB) RP-HPLC (171 KB)

Handling Instructions (2659 KB)

References

[1]. Yu G, et al. Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke [published correction appears in J Neuroinflammation. 2016;13(1):166]. J Neuroinflammation. 2016;13(1):11 [Content Brief]

[2]. Zhang H, et al. N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor. J Lipid Res. 2013;54(11):3016-3029. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.2048 mL	11.0239 mL	22.0478 mL	55.1195 mL
	5 mM	0.4410 mL	2.2048 mL	4.4096 mL	11.0239 mL
	10 mM	0.2205 mL	1.1024 mL	2.2048 mL	5.5119 mL
	15 mM	0.1470 mL	0.7349 mL	1.4699 mL	3.6746 mL
	20 mM	0.1102 mL	0.5512 mL	1.1024 mL	2.7560 mL
	25 mM	0.0882 mL	0.4410 mL	0.8819 mL	2.2048 mL
	30 mM	0.0735 mL	0.3675 mL	0.7349 mL	1.8373 mL
	40 mM	0.0551 mL	0.2756 mL	0.5512 mL	1.3780 mL
	50 mM	0.0441 mL	0.2205 mL	0.4410 mL	1.1024 mL
	60 mM	0.0367 mL	0.1837 mL	0.3675 mL	0.9187 mL
	80 mM	0.0276 mL	0.1378 mL	0.2756 mL	0.6890 mL
	100 mM	0.0220 mL	0.1102 mL	0.2205 mL	0.5512 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.