2. MAPK/ERK Pathway
  3. p38 MAPK
  4. NJK14047

NJK14047 inhibits p38 MAPK and the differentation of naive T-cells to Th1 and Th17 cells. NJK14047 ameliorates the collage-induced rheumatoid arthritis and Imiquimod (HY-B0180)-induced psoriasis in mice.

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NJK14047 Chemical Structure

NJK14047 Chemical Structure

CAS No. : 1800576-41-3

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Description

NJK14047 inhibits p38 MAPK and the differentation of naive T-cells to Th1 and Th17 cells. NJK14047 ameliorates the collage-induced rheumatoid arthritis and Imiquimod (HY-B0180)-induced psoriasis in mice[1].

In Vitro

NJK14047 (3-10 μM) inhibits expressions of inflammatory cytokines IL-1β, TNF-α, IL-6, IL-17A, RANKL, and MMP-3 in Lipopolysaccharid (HY-D1056) stimulated human SW982 synovial cells[1].
NJK14047 (3-10 μM) inhibits the differentation of naive CD4+T cells into Th1, Th2 and Th17 cells in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NJK14047 Related Antibodies
In Vivo

NJK14047 (2.5 mg/kg, i.p. for 7-21 days) ameliorates the collage-induced rehumatoid arthritis (CIA) in DBA-1J mice and Imiquimod (HY-B0180)-induced psoriasis (IIP) in BALB/c mice, suppresses the cytokines expressions of Th1, Th2, Th17 and Treg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: collage-induced rehumatoid arthritis in DBA-1J mice and imiquimod-induced psoriasis in BALB/c mice[1]
Dosage: 2.5 mg/kg
Administration: i.p. for 7 days for IIP-administrated BALB/c mice, i.p. for 21 days for CIA-administrated CBA-1J mice
Result: Ameliorated the collage-induced arthritis and CIA caused cartilage damage, inflammation, pannus formation, bone corrosion, and synovial hyperplasia.
Ameliorated the imiquimod induced psoriasis and IIP caused keratinocyte proliferation.
Molecular Weight

445.51

Formula

C27H27NO5
CAS No.
SMILES

O=C(C1=CC(C2=CC=C(C(C3=CC=C(OCC(O)CO)C=C3)=O)C=C2)=C(C)C=C1)NC4CC4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NJK14047 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NJK140471800576-41-3NJK 14047NJK-14047p38 MAPKDBA-1J mouseBALB/cSW982arthritispsoriasisInhibitorinhibitorinhibit

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