Nusinersen

Cat. No.: HY-112980: FAQs
Data Sheet SDS Handling Instructions

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Nusinersen is an antisense oligonucleotide agent that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Nusinersen sodium) that retains the same biological activity.

For research use only. We do not sell to patients.

RNA, [2'-O-(2-methoxyethyl)](P-thio)(m5U-m5C-A-m5C-m5U-m5U-m5U-m5C-A-m5U-A-A-m5U-G-m5C-m5U-G-G)

Nusinersen Chemical Structure

CAS No. : 1258984-36-9

Size	Price	Stock
1 mg	USD 420	Ask For Quote & Lead Time
5 mg	USD 1246	Ask For Quote & Lead Time
10 mg	USD 1890	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Nusinersen:

Other Forms of Nusinersen:

Nusinersen sodium In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Nusinersen is an antisense oligonucleotide agent that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein^[1].

In Vitro

Nusinersen is an SMN-ASO that increases SMN levels by blocking an intronic splice silencer in SMN2, thereby facilitating the exon 7 inclusion and generation of FL-SMN2 transcripts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

7127.30

CAS No.

1258984-36-9

Appearance

Solid

Color

White to off-white

Sequence

RNA, [2'-O-(2-methoxyethyl)](P-thio)(m5U-m5C-A-m5C-m5U-m5U-m5U-m5C-A-m5U-A-A-m5U-G-m5C-m5U-G-G)

SMILES

[Nusinersen]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Purity & Documentation

Data Sheet (285 KB) SDS (420 KB) Handling Instructions (2659 KB)

References

[1]. Richard S Finkel, et al. Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy. N Engl J Med. 2017 Nov 2;377(18):1723-1732. [Content Brief]

[2]. Laura Torres-Benito, et al. NCALD Antisense Oligonucleotide Therapy in Addition to Nusinersen further Ameliorates Spinal Muscular Atrophy in Mice. Am J Hum Genet. 2019 Jul 3;105(1):221-230. [Content Brief]

Nusinersen Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nusinersen1258984-36-9DNA/RNA SynthesisSMAspinalmuscularatrophySMN2Inhibitorinhibitorinhibit

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