2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK Stem Cell/Wnt
  3. Casein Kinase DYRK
  4. ON 108600

ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity.

For research use only. We do not sell to patients.

ON 108600 Chemical Structure

ON 108600 Chemical Structure

CAS No. : 1585246-23-6

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1 mg USD 290 In-stock
5 mg USD 630 In-stock
10 mg USD 1020 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

ON 108600 Related Antibodies

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  • Biological Activity

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Description

ON 108600 is a inhibitor for CK2 (Casein Kinase2)/TNIK/DYRK1 , with the IC50s for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM, respectively. ON 108600 has antitumor activity[1].

IC50 & Target

DYRK2

0.028 μM (IC50)

DYRK1A

0.016 μM (IC50)

DYRK1B

0.007 μM (IC50)

CK2α2

0.005 μM (IC50)

CK2α1

0.05 μM (IC50)

Molecular Weight

537.39

Formula

C22H14Cl2N2O6S2
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

ClC(C=CC=C1Cl)=C1CS(=O)(C2=CC=C(S/C(C(N3)=O)=C\C4=CC([N+]([O-])=O)=C(C=C4)O)C3=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (186.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8608 mL 9.3042 mL 18.6085 mL
5 mM 0.3722 mL 1.8608 mL 3.7217 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8608 mL 9.3042 mL 18.6085 mL 46.5211 mL
5 mM 0.3722 mL 1.8608 mL 3.7217 mL 9.3042 mL
10 mM 0.1861 mL 0.9304 mL 1.8608 mL 4.6521 mL
15 mM 0.1241 mL 0.6203 mL 1.2406 mL 3.1014 mL
20 mM 0.0930 mL 0.4652 mL 0.9304 mL 2.3261 mL
25 mM 0.0744 mL 0.3722 mL 0.7443 mL 1.8608 mL
30 mM 0.0620 mL 0.3101 mL 0.6203 mL 1.5507 mL
40 mM 0.0465 mL 0.2326 mL 0.4652 mL 1.1630 mL
50 mM 0.0372 mL 0.1861 mL 0.3722 mL 0.9304 mL
60 mM 0.0310 mL 0.1551 mL 0.3101 mL 0.7754 mL
80 mM 0.0233 mL 0.1163 mL 0.2326 mL 0.5815 mL
100 mM 0.0186 mL 0.0930 mL 0.1861 mL 0.4652 mL
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ON 108600 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ON 1086001585246-23-6ON108600ON-108600Casein KinaseDYRKDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinaseCasein Kinase/DYRK/TNIK InhibitorTriple negative breast cancer (TNBC)?Inhibitorinhibitorinhibit

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