2. Membrane Transporter/Ion Channel Apoptosis
  3. P-glycoprotein Apoptosis
  4. P-gp inhibitor 22

P-gp inhibitor 22 is a P-glycoprotein (P-gp) inhibitor that effectively inhibits P-pg and efflux function. P-gp inhibitor 22 induces apoptosis and accumulation of MCF-7/ADR cells processed in the S phase.

For research use only. We do not sell to patients.

P-gp inhibitor 22 Chemical Structure

P-gp inhibitor 22 Chemical Structure

CAS No. : 1226674-74-3

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

P-gp inhibitor 22 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

P-gp inhibitor 22 is a P-glycoprotein (P-gp) inhibitor that effectively inhibits P-pg and efflux function. P-gp inhibitor 22 induces apoptosis and accumulation of MCF-7/ADR cells processed in the S phase[1].

In Vitro

P-gp inhibitor 22 (compound 4b; 6.25-100 μM; 24 h) demonstrates significant vigour against MCF-7/ADR cells[1].
P-gp inhibitor 22 (compound 4b; 5 μM; 24 h) induces apoptosis and accumulation of MCF-7/ADR cells processed in the S phase[1].
P-gp inhibitor 22 inhibits a variety cell lines, such as PC-3, SKOV-3, HeLa, MCF-7/ADR, HFL-1, and WI-38 cells, the IC50 values of 3.3 μM, 0.7 μM, 2.4 μM, 5.0 μM, 72.0 μM, and 61.1 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

P-gp inhibitor 22 Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-7/ADR cells
Concentration: 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM
Incubation Time: 24 h
Result: Showed dose-dependent cytotoxicity in MCF-7/ADR cells.

Cell Cycle Analysis[1]

Cell Line: MCF-7/ADR cells
Concentration: 5 μM
Incubation Time: 24 h
Result: Showed cell cycle arrest at S phase and induced apoptosis.
Molecular Weight

348.78

Formula

C20H13ClN2O2
CAS No.
Unlabeled CAS

SMILES

N#CC1=C(N)OC2=C(C3=CC(O)=CC=C3C=C2)C1C4=CC=CC=C4Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

P-gp inhibitor 22 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-gp inhibitor 221226674-74-3P-glycoproteinApoptosisP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243P-glycoprotein inhibitorefflux functionapoptosisS phaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
P-gp inhibitor 22
Cat. No.:
HY-162447
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.