2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. PAPA NONOate

PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site.

For research use only. We do not sell to patients.

PAPA NONOate Chemical Structure

PAPA NONOate Chemical Structure

CAS No. : 146672-58-4

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Based on 1 publication(s) in Google Scholar

PAPA NONOate Related Antibodies

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Description

PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3].

In Vitro

PAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PAPA NONOate Related Antibodies
In Vivo

PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2]
Dosage: 100 μM
Administration: Wounds received 100 μM PAPA NONOate in phosphate buffer
Result: Increased the wound healing rate in test group.
Molecular Weight

176.22

Formula

C6H16N4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCCCN(CCC)N(O)N=O
Structure Classification
Initial Source
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (283.74 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6747 mL 28.3736 mL 56.7472 mL
5 mM 1.1349 mL 5.6747 mL 11.3494 mL
View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.6747 mL 28.3736 mL 56.7472 mL 141.8681 mL
5 mM 1.1349 mL 5.6747 mL 11.3494 mL 28.3736 mL
10 mM 0.5675 mL 2.8374 mL 5.6747 mL 14.1868 mL
15 mM 0.3783 mL 1.8916 mL 3.7831 mL 9.4579 mL
20 mM 0.2837 mL 1.4187 mL 2.8374 mL 7.0934 mL
25 mM 0.2270 mL 1.1349 mL 2.2699 mL 5.6747 mL
30 mM 0.1892 mL 0.9458 mL 1.8916 mL 4.7289 mL
40 mM 0.1419 mL 0.7093 mL 1.4187 mL 3.5467 mL
50 mM 0.1135 mL 0.5675 mL 1.1349 mL 2.8374 mL
60 mM 0.0946 mL 0.4729 mL 0.9458 mL 2.3645 mL
80 mM 0.0709 mL 0.3547 mL 0.7093 mL 1.7734 mL
100 mM 0.0567 mL 0.2837 mL 0.5675 mL 1.4187 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PAPA NONOate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAPA NONOate146672-58-4Endogenous Metabolitenitric oxidehalf-lifewound healingcollagen synthesisdiabetesInhibitorinhibitorinhibit

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