2. Apoptosis
  3. Apoptosis Caspase
  4. Patuletin

Patuletin is a flavonol, that can be isolated from the flowers of Tagetes patula. Patuletin shows anti-proliferative activity against cancer cells. Patuletin causes significant nuclear fragmentation and has a great capacity to induce caspase-3 activation.

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Patuletin Chemical Structure

Patuletin Chemical Structure

CAS No. : 519-96-0

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Patuletin Related Antibodies

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Description

Patuletin is a flavonol, that can be isolated from the flowers of Tagetes patula. Patuletin shows anti-proliferative activity against cancer cells. Patuletin causes significant nuclear fragmentation and has a great capacity to induce caspase-3 activation[1][2].

IC50 & Target

Caspase 3

 

In Vitro

Patuletin (0-100 μg/mL, 24 h) shows anti-proliferative activity against cancer cells[2].
Patuletin induces apoptosis in the CaSki, MDA-MB-231, and SK-Lu-1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Patuletin Related Antibodies

Cell Proliferation Assay[2]

Cell Line: CaSki, MDA-MB-231 and SK-Lu-1
Concentration: 6, 12, 25, 50 and 100 μg/mL
Incubation Time: 24 h
Result: Showed a dose-dependent proliferation inhibition, with IC50 values of 37, 86, and 18 μg/mL for CaSki, MDA-MB-231 and SK-Lu-1 cells, respectively.
Molecular Weight

332.26

Formula

C16H12O8
CAS No.
SMILES

O=C1C(O)=C(C2=CC(O)=C(O)C=C2)OC3=CC(O)=C(C(O)=C13)OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Patuletin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Patuletin519-96-0ApoptosisCaspaseCaSkiMDA-MB-231SK-Lu-1Inhibitorinhibitorinhibit

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