2. Anti-infection
  3. Bacterial
  4. Pexiganan

Pexiganan  (Synonyms: MSI 78 free base)

Cat. No.: HY-105088 Purity: 98.66%
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Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Pexiganan Chemical Structure

Pexiganan Chemical Structure

CAS No. : 147664-63-9

Size Price Stock Quantity
5 mg USD 109 In-stock
10 mg USD 185 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Pexiganan Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pexiganan (MSI 78 free base) is a synthetic analog of magainin 2. Pexiganan is a potent and orally active broad-spectrum antimicrobial peptide. Pexiganan can be used in the research of infections, such as diabetic foot ulcer infections[1].

In Vitro

Pexiganan (MIC: 0-128 μg/mL approximately) shows broad-spectrum antibacterial activity against 3,109 clinical isolates of gram-positive and gram-negative, anaerobic and aerobic bacteria[2].
Pexiganan (4 μg/mL) inhibits gastric ulcer strain and gastric cancer strain[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pexiganan Related Antibodies
In Vivo

Pexiganan (1, 3, 10 or 30 mg/kg, p.o., daily for three consecutive days) shows H. pylori clearance efficiency in H. pylori-infected mouse[3].
Pexiganan (1 mg/kg, i.p.) shows antimicrobial activity in rat models of Gram-negative septic shock[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: H. pylori-infected mouse[3].
Dosage: 1, 3, 10 or 30 mg/kg
Administration: Oral administration, daily for three consecutive days.
Result: Lowered H. pylori urease activities in mouse stomachs.
Animal Model: Rat models of Gram-negative septic shock (induced by E.coli ATCC 25922)[4].
Dosage: 1 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Displayed antimicrobial activities and survival rates of 67.7%.
Clinical Trial
Molecular Weight

2477.17

Formula

C122H210N32O22
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

GIGKFLKKAKKFGKAFVKILKK-NH2
Structure Classification
Initial Source

the skin of the African clawed frog
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (40.37 mM; Need ultrasonic)

DMSO : 5 mg/mL (2.02 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4037 mL 2.0184 mL 4.0369 mL
5 mM 0.0807 mL 0.4037 mL 0.8074 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.4037 mL 2.0184 mL 4.0369 mL 10.0922 mL
H2O 5 mM 0.0807 mL 0.4037 mL 0.8074 mL 2.0184 mL
10 mM 0.0404 mL 0.2018 mL 0.4037 mL 1.0092 mL
15 mM 0.0269 mL 0.1346 mL 0.2691 mL 0.6728 mL
20 mM 0.0202 mL 0.1009 mL 0.2018 mL 0.5046 mL
25 mM 0.0161 mL 0.0807 mL 0.1615 mL 0.4037 mL
30 mM 0.0135 mL 0.0673 mL 0.1346 mL 0.3364 mL
40 mM 0.0101 mL 0.0505 mL 0.1009 mL 0.2523 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pexiganan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pexiganan147664-63-9MSI 78MSI78MSI-78BacterialMagainin 2antimicrobialinfectionH. pylorigastric ulcersepsisseptic shockInhibitorinhibitorinhibit

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