2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton Metabolic Enzyme/Protease Epigenetics
  3. ROCK SGK PKA PKC
  4. PF-4950834

PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive rho kinase inhibitor with IC50 values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration.

For research use only. We do not sell to patients.

PF-4950834 Chemical Structure

PF-4950834 Chemical Structure

CAS No. : 1256264-62-6

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PF-4950834 Related Antibodies

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Description

PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive rho kinase inhibitor with IC50 values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration[1].

IC50 & Target

ROCK2

8.35 nM (IC50)

ROCK1

33.12 nM (IC50)

PKA

424 nM (IC50)

PKCη

756 nM (IC50)

In Vitro

PF-4950834 shows inhibition against the AGC (cAMP-dependent protein kinase/protein kinase G/protein kinase C) kinase family with IC50 values of 8.35, 33.12, 102, 216, 321, 384, 411, 424, 457, 578, 736, 756 and 2900 nM for ROCK2, ROCK1, PRKG1, PKN1, SGK2, PRKG2, MSK1, PKA, PRKX, MSK2, P70S6K, PKCη and SGK1, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-4950834 Related Antibodies
Molecular Weight

345.39

Formula

C21H19N3O2
CAS No.
SMILES

O=C(NC)C1=CC=CC(CNC(C2=CC=C(C3=CC=NC=C3)C=C2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PF-4950834 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-49508341256264-62-6PF4950834PF 4950834ROCKSGKPKAPKCRho-associated protein kinaseRho-associated kinaseRho-kinaseROKSerum-glucocorticoid regulated kinaseSerum and glucocorticoid-regulated kinaseProtein kinase AProtein kinase Cneutrophil migrationanti-inflammatoryAGC kinase familyorally bioavailableInhibitorinhibitorinhibit

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