PM-81I

Cat. No.: HY-148093: FAQs
Data Sheet Handling Instructions

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PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer^[1].

For research use only. We do not sell to patients.

PM-81I Chemical Structure

CAS No. : 1637532-83-2

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References
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Description

IC₅₀ & Target

STAT6^[1].

In Vitro

PM-81I (0.05, 0.1, 0.5, 1, 2.5, 5 µM; 2 h) inhibits IL-4 stimulated phosphorylation of STAT6 in Bease-2B immortalized human epithelial airway cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	Bease-2B immortalized human epithelial airway cells
Concentration:	0.05, 0.1, 0.5, 1, 2.5, 5 µM
Incubation Time:	2 h
Result:	Decreased phosphorylation levels of STAT6 to18%, 13%, 13% when at 1, 2.5 and 5 µM, respectively.

Molecular Weight

845.91

Formula

C₄₃H₅₈F₂N₃O₁₀P

CAS No.

1637532-83-2

SMILES

O=C(N1CC2=CC=CC=C2CC1)[C@H]3N(CCC3)C([C@H](C(C)(C)C)NC(/C=C(C4=CC=C(C=C4)C(F)(F)P(OCOC(C(C)(C)C)=O)(OCOC(C(C)(C)C)=O)=O)\C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. John S, et al. Stat6 inhibitors. Patent WO2014182928A2.

PM-81I Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PM-81I1637532-83-2STATasthmaBease-2B immortalized human epithelial airway cellsallergic lung diseaseallergic rhinitiscancerInhibitorinhibitorinhibit

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