2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pom-8PEG

Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader.

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Pom-8PEG Chemical Structure

Pom-8PEG Chemical Structure

CAS No. : 2488761-03-9

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5 mg USD 160 In-stock
10 mg USD 260 In-stock
25 mg USD 520 In-stock
50 mg USD 840 In-stock
100 mg USD 1350 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

625.66

Formula

C29H43N3O12
CAS No.
Appearance

Viscous Liquid

Color

Light green to green

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOCCOCCOCCOCCO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (159.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5983 mL 7.9916 mL 15.9831 mL
5 mM 0.3197 mL 1.5983 mL 3.1966 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5983 mL 7.9916 mL 15.9831 mL 39.9578 mL
5 mM 0.3197 mL 1.5983 mL 3.1966 mL 7.9916 mL
10 mM 0.1598 mL 0.7992 mL 1.5983 mL 3.9958 mL
15 mM 0.1066 mL 0.5328 mL 1.0655 mL 2.6639 mL
20 mM 0.0799 mL 0.3996 mL 0.7992 mL 1.9979 mL
25 mM 0.0639 mL 0.3197 mL 0.6393 mL 1.5983 mL
30 mM 0.0533 mL 0.2664 mL 0.5328 mL 1.3319 mL
40 mM 0.0400 mL 0.1998 mL 0.3996 mL 0.9989 mL
50 mM 0.0320 mL 0.1598 mL 0.3197 mL 0.7992 mL
60 mM 0.0266 mL 0.1332 mL 0.2664 mL 0.6660 mL
80 mM 0.0200 mL 0.0999 mL 0.1998 mL 0.4995 mL
100 mM 0.0160 mL 0.0799 mL 0.1598 mL 0.3996 mL
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Pom-8PEG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pom-8PEG2488761-03-9E3 Ligase Ligand-Linker ConjugatesimmunecheckpointCRBNPEGlinkerdegraderInhibitorinhibitorinhibit

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