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  3. Isotope-Labeled Compounds
  4. Ponesimod-d7

Ponesimod-d7  (Synonyms: ACT-128800-d7)

Cat. No.: HY-10569S1 Purity: 96.50%
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Ponesimod-d7 (ACT-128800-d7) is the deuterium-labeled Ponesimod (HY-10569). Ponesimod-d7 (ACT-128800) is a potent, selective and orally active agonist of S1P1, with an IC50 of 6 nM in a radioligand binding assay. Ponesimod-d7 activates S1P1-mediated signal transduction with high potency (EC50=5.7 nM). Ponesimod-d7 can protect against lymphocyte-mediated tissue inflammation.

For research use only. We do not sell to patients.

Ponesimod-d<sub>7</sub> Chemical Structure

Ponesimod-d7 Chemical Structure

Size Price Stock Quantity
1 mg USD 400 In-stock
5 mg USD 980 In-stock
10 mg USD 1600 In-stock
25 mg USD 3200 In-stock
50 mg USD 5200 In-stock
100 mg USD 8400 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Ponesimod-d7:

Ponesimod-d7 Related Antibodies

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Description

Ponesimod-d7 (ACT-128800-d7) is the deuterium-labeled Ponesimod (HY-10569). Ponesimod-d7 (ACT-128800) is a potent, selective and orally active agonist of S1P1, with an IC50 of 6 nM in a radioligand binding assay. Ponesimod-d7 activates S1P1-mediated signal transduction with high potency (EC50=5.7 nM). Ponesimod-d7 can protect against lymphocyte-mediated tissue inflammation[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ponesimod-d7 Related Antibodies
Molecular Weight

468.02

Formula

C23H18D7ClN2O4S
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C2=C([2H])C([2H])=C([2H])C([2H])=C2C([2H])([2H])[2H])/C(S/C1=C\C3=CC=C(OC[C@H](O)CO)C(Cl)=C3)=N/CCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (213.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1367 mL 10.6833 mL 21.3666 mL
5 mM 0.4273 mL 2.1367 mL 4.2733 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1367 mL 10.6833 mL 21.3666 mL 53.4165 mL
5 mM 0.4273 mL 2.1367 mL 4.2733 mL 10.6833 mL
10 mM 0.2137 mL 1.0683 mL 2.1367 mL 5.3417 mL
15 mM 0.1424 mL 0.7122 mL 1.4244 mL 3.5611 mL
20 mM 0.1068 mL 0.5342 mL 1.0683 mL 2.6708 mL
25 mM 0.0855 mL 0.4273 mL 0.8547 mL 2.1367 mL
30 mM 0.0712 mL 0.3561 mL 0.7122 mL 1.7806 mL
40 mM 0.0534 mL 0.2671 mL 0.5342 mL 1.3354 mL
50 mM 0.0427 mL 0.2137 mL 0.4273 mL 1.0683 mL
60 mM 0.0356 mL 0.1781 mL 0.3561 mL 0.8903 mL
80 mM 0.0267 mL 0.1335 mL 0.2671 mL 0.6677 mL
100 mM 0.0214 mL 0.1068 mL 0.2137 mL 0.5342 mL
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Ponesimod-d7 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ponesimod-d7ACT-128800-d7Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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