2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Angiopoietins
  5. Angiopoietin Like 3 Proteins

Angiopoietin Like 3 Proteins

Recombinant Protein Expression Service

Angiopoietin Like 3 Proteins

Related Products

XLSX 4.03 KB

Angiopoietin-like proteins (ANGPTLs) are identified as a family of proteins structurally similar to the angiopoietins. Eight ANGPTLs have been discovered, namely ANGPTL1 to ANGPTL8. ANGPTLs do not bind to the receptors classically targeted by angiopoietins, Tie-1/2, and have been generally considered orphan ligands. Similar to angiopoietins, ANGPTLs are able to potently regulate angiogenesis.
Most of the ANGPTLs exhibit multibiological properties, including established functional roles in lipid and glucose metabolism, inflammation, hematopoiesis, and cancer. For example, ANGPTL 2, 3, 4, 6 and 7 are pro-inflammatory factors and regulate cancer progression, while ANGPTL1 inhibits tumor angiogenesis and metastasis.

Subscribe Now to the List of Recombinant Proteins

Cat. No. Product Name / Synonyms Species Source
  • HY-P78059
    ANGPTL3/Angiopoietin-like 3 Protein, Human (Biotinylated, HEK293, His-Avi)

    ANGPTL3; ANGPT5; ANG-5; Angiopoietin-5; FHBL2; ANL3; Angiopoietin-5; Angiopoietin-like Protein 3

    		Human HEK293
    ANGPTL3/Angiopoietin-like 3 protein, a hepatokine, intricately regulates lipid and glucose metabolism. It stimulates plasma triglycerides by inhibiting lipoprotein lipase (LPL), suppressing TG clearance through PCSK6 and FURIN recruitment, independent of proteolytic cleavage and unaffected by GPIHBP1. ANGPTL3 inhibits endothelial lipase, elevating HDL cholesterol, and activates adipocyte lipolysis. It selectively suppresses LPL in oxidative tissues, directing VLDL-TG to white adipose tissue, potentially cooperating with ANGPTL8 and ANGPTL4. ANGPTL3 also lowers LDL cholesterol independently of the canonical APOE and LDLR pathway, and may stimulate hypothalamic LPL activity. ANGPTL3/Angiopoietin-like 3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ANGPTL3/Angiopoietin-like 3 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of ANGPTL3/Angiopoietin-like 3 Protein, Human (Biotinylated, HEK293, His-Avi) is 203 a.a., with molecular weight of 30-38 kDa.
  • HY-P7505
    ANGPTL3/Angiopoietin-like 3 Protein, Human (204a.a, HEK293, His)

    rHuAngiopoietin-like Protein 3, His; ANGPTL3; Angiopoietin-like Protein 3

    		Human HEK293
    ANGPTL3/Angiopoietin-like 3 Protein, Human (204a.a, HEK293, His) plays an important role in lipoprotein metabolism. Angiopoietin-like Protein 3 acts as a dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL). Angiopoietin-like Protein 3 inhibits endothelial lipase hydrolysis of HDL-phospholipid (PL), thereby increasing HDL-PL levels.
  • HY-P7504
    ANGPTL3/Angiopoietin-like 3 Protein, Mouse (HEK293, His)

    rMuAngiopoietin-like Protein 3, His; ANGPTL3; Angiopoietin-like Protein 3

    		Mouse HEK293
    ANGPTL3/Angiopoietin-like 3 Protein, Mouse (HEK293, His) is a mouse recombinant ANGPTL3 with a 10-His tag at the C-terminus. Angiopoietin-like Protein 3, Mouse (HEK293, His) is produced by Mammalian expression system and the target gene encoding Ser17-Thr455 is expressed.
  • HY-P78379
    ANGPTL3/Angiopoietin-like 3 Protein, Human (HEK293, His-Avi)

    ANGPTL3; ANGPT5; ANG-5; Angiopoietin-5; FHBL2; ANL3; Angiopoietin-5; Angiopoietin-like Protein 3

    		Human HEK293
    ANGPTL3/Angiopoietin-like 3 protein, a hepatokine, intricately regulates lipid and glucose metabolism. It stimulates plasma triglycerides by inhibiting lipoprotein lipase (LPL), suppressing TG clearance through PCSK6 and FURIN recruitment, independent of proteolytic cleavage and unaffected by GPIHBP1. ANGPTL3 inhibits endothelial lipase, elevating HDL cholesterol, and activates adipocyte lipolysis. It selectively suppresses LPL in oxidative tissues, directing VLDL-TG to white adipose tissue, potentially cooperating with ANGPTL8 and ANGPTL4. ANGPTL3 also lowers LDL cholesterol independently of the canonical APOE and LDLR pathway, and may stimulate hypothalamic LPL activity. ANGPTL3/Angiopoietin-like 3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived ANGPTL3/Angiopoietin-like 3 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of ANGPTL3/Angiopoietin-like 3 Protein, Human (HEK293, His-Avi) is 203 a.a., with molecular weight of 30-38 kDa.
  • HY-P75580
    ANGPTL3/Angiopoietin-like 3 Protein, Human (sf9, His)

    Angiopoietin-5; ANG-5; ANGPTL3; ANGPT5; UNQ153/PRO179

    		Human Sf9 insect cells
    ANGPTL3/Angiopoietin-like 3 protein, a hepatokine, intricately regulates lipid and glucose metabolism. It stimulates plasma triglycerides by inhibiting lipoprotein lipase (LPL), suppressing TG clearance through PCSK6 and FURIN recruitment, independent of proteolytic cleavage and unaffected by GPIHBP1. ANGPTL3 inhibits endothelial lipase, elevating HDL cholesterol, and activates adipocyte lipolysis. It selectively suppresses LPL in oxidative tissues, directing VLDL-TG to white adipose tissue, potentially cooperating with ANGPTL8 and ANGPTL4. ANGPTL3 also lowers LDL cholesterol independently of the canonical APOE and LDLR pathway, and may stimulate hypothalamic LPL activity. ANGPTL3/Angiopoietin-like 3 Protein, Human (sf9, His) is the recombinant human-derived ANGPTL3/Angiopoietin-like 3 protein, expressed by Sf9 insect cells, with C-His labeled tag. The total length of ANGPTL3/Angiopoietin-like 3 Protein, Human (sf9, His) is 460 a.a., with molecular weight of ~53.3 kDa.
  • HY-P700954
    ANGPTL3/Angiopoietin-like 3 Protein, Cynomolgus (HEK293, His)

    ANGPTL3; ANGPT5; ANG-5; Angiopoietin-5; FHBL2; ANL3; Angiopoietin-5; Angiopoietin-like Protein 3

    		Cynomolgus HEK293
    ANGPTL3/angiopoietin-like 3 protein is a hepatic factor that complexly regulates lipid and glucose metabolism. It stimulates plasma triglycerides by inhibiting lipoprotein lipase (LPL), inhibits TG clearance through PCSK6 and FURIN recruitment, is independent of proteolytic cleavage, and is not affected by GPIHBP1. ANGPTL3/Angiopoietin-like 3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived ANGPTL3/Angiopoietin-like 3 protein, expressed by HEK293 , with C-His labeled tag. The total length of ANGPTL3/Angiopoietin-like 3 Protein, Cynomolgus (HEK293, His) is 444 a.a., with molecular weight of 60-70 kDa.
  • HY-P76726
    ANGPTL3/Angiopoietin-like 3 Protein, Cynomolgus (sf9, His)

    Angiopoietin-related protein 3; Angiopoietin-5; ANG-5; ANGPT5

    		Cynomolgus Sf9 insect cells
    ANGPTL3/Angiopoietin-like 3 is a vascular growth factor and a member of the angiopoietin like protein family. It has high specificity for endothelial cells, performs various other regulatory activities to affect inflammation, and has been proved to have atherosclerosis promoting and atherosclerosis protective effects. NGPTL3/Angiopoietin-like 3 can also inhibit the activity of lipoprotein lipase and induce angiogenesis. ANGPTL3/Angiopoietin-like 3 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived ANGPTL3/Angiopoietin-like 3 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of ANGPTL3/Angiopoietin-like 3 Protein, Cynomolgus (sf9, His) is 220 a.a., with molecular weight of ~25.2 KDa.
Cat. No. Product Name Effect Purity