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The cluster of differentiation (CD) antigens is a protocol used for the identification and investigation of cell surface molecules present on leukocytes. Some CD proteins often act as cell-cell or cell-matrix adhesion molecules, cytokine receptors, ion pores, or nutrient transporters. Some CD proteins play a role in cell signaling, other CD molecules mediate cell adhesion. Cell adhesion is a dynamic process by which cells form contacts with each other or with their substratum through specialized protein complexes. Cell-cell adhesion helps shape tissue organization during morphogenesis and preserves tissue cohesion in post-developmental life. MCE offers a variety of recombination CD antigens related to cell adhesion research.
Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD24; CD24A
Human
HEK293
CD24 protein plays a pivotal role in cell differentiation across various cell types, with signaling potentially initiated by lectin-like ligand binding to CD24 carbohydrates, transduced through second messengers released from the GPI-anchor. CD24 also modulates B-cell activation responses, promoting AG-dependent B-cell proliferation and preventing terminal differentiation into antibody-forming cells. In association with SIGLEC10, CD24 contributes to the selective suppression of the immune response to DAMPs such as HMGB1, HSP70, and HSP90, suggesting a role in immune regulation. Additionally, CD24 is implicated in controlling autoimmunity, exhibiting cell-type-specific interactions with LYN and FGR in diverse cellular processes and immune regulation. CD24 Protein, Human (S44T, HEK293, Fc) is the recombinant human-derived CD24 protein, expressed by HEK293 , with C-hFc labeled tag and S44T mutation. The total length of CD24 Protein, Human (S44T, HEK293, Fc) is 33 a.a., with molecular weight of 40-55 kDa.
The CD5 protein is a potential receptor that regulates T cell proliferation. Its interactions with CD72/LYB-2 and PTPN6/SHP-1 indicate multifaceted roles in cellular processes, serving as key mediators of T cell responses. CD5 Protein, Human (HEK293, His) is the recombinant human-derived CD5 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD5 Protein, Human (HEK293, His) is 348 a.a., with molecular weight of ~48.9 kDa.
The CD6 protein is a cell adhesion molecule that mediates cell-cell contacts and regulates T cell responses through interaction with ALCAM/CD166. It functions as a costimulatory molecule, promoting T cell activation, proliferation, and contributing to the formation of immune synapses. CD6 Protein, Human (HEK293, Fc) is the recombinant human-derived CD6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD6 Protein, Human (HEK293, Fc) is 381 a.a., with molecular weight of ~67.3 kDa.
The CD5 protein is a potential receptor that regulates T cell proliferation. Its interactions with CD72/LYB-2 and PTPN6/SHP-1 indicate multifaceted roles in cellular processes, serving as key mediators of T cell responses. CD5 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived CD5 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of CD5 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 347 a.a., with molecular weight of 70-80 kDa.
CD24 protein plays a pivotal role in cell differentiation across various cell types, with signaling potentially initiated by lectin-like ligand binding to CD24 carbohydrates, transduced through second messengers released from the GPI-anchor. CD24 also modulates B-cell activation responses, promoting AG-dependent B-cell proliferation and preventing terminal differentiation into antibody-forming cells. In association with SIGLEC10, CD24 contributes to the selective suppression of the immune response to DAMPs such as HMGB1, HSP70, and HSP90, suggesting a role in immune regulation. Additionally, CD24 is implicated in controlling autoimmunity, exhibiting cell-type-specific interactions with LYN and FGR in diverse cellular processes and immune regulation. CD24 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD24 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of CD24 Protein, Human (Biotinylated, HEK293, His-Avi) is 33 a.a., with molecular weight of 18-33 kDa.
CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (Biotinylated, HEK293) is the recombinant human-derived CD44 protein, expressed by HEK293 , with C-Avi, C-mFc labeled tag. The total length of CD44 Protein, Human (Biotinylated, HEK293) is 200 a.a., with molecular weight of 51 kDa.
CD2 Protein mediates T-cell adhesion to other cell types by interacting with CD58 (LFA-3) and CD48/BCM1. Implicated in T-cell triggering, its cytoplasmic domain has signaling functions. CD2 also interacts with CD2AP and PSTPIP1. Moreover, its interaction with FCGR3A modulates NK cell activation and cytotoxicity. CD2 Protein, Cynomolgus (HEK293, His, solution) is the recombinant cynomolgus-derived CD2 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD2 Protein, Cynomolgus (HEK293, His, solution) is 185 a.a., with molecular weight of ~35.7 kDa.
CD5 Protein lacks conserved residue(s) essential for feature annotation propagation. CD5 Protein, Rhesus Macaque (HEK293, His-Avi) is the recombinant Rhesus Macaque-derived CD5 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of CD5 Protein, Rhesus Macaque (HEK293, His-Avi) is 351 a.a., with molecular weight of 55-60 kDa.
CD44 is a cell surface receptor that plays a key role in calcium mobilization and actin-mediated cytoskeletal reorganization, cell migration, and adhesion. CD44 Protein, Human (HEK293, His) is the recombinant human-derived CD44 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD44 Protein, Human (HEK293, His) is 200 a.a., with molecular weight of 38-50 kDa.
CD9 protein is an integral membrane protein that plays a critical regulatory role in processes such as sperm-egg fusion, platelet activation, and cell adhesion. CD9 is critical for sperm-egg fusion, coordinating multi-protein complexes on the oocyte surface. CD9 Protein, Human (HEK293, His) is the recombinant human-derived CD9 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD9 Protein, Human (HEK293, His) is 84 a.a., with molecular weight of ~10 kDa.
CD6, a protein, lacks essential conserved residue(s) necessary for propagating feature annotation. CD6 Protein, Rat (HEK293, His) is the recombinant rat-derived CD6 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD6 Protein, Rat (HEK293, His) is 379 a.a., with molecular weight of ~60-90 kDa.
CD5 protein, a pivotal T-cell receptor, regulates T-cell proliferation through interactions with CD72/LYB-2. Its potential interaction with PTPN6/SHP-1 underscores its involvement in critical signaling pathways. CD5 Protein, Rat (HEK293, His) is the recombinant rat-derived CD5 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD5 Protein, Rat (HEK293, His) is 345 a.a., with molecular weight of ~50-56 kDa.
Adhesion G protein-coupled receptor E5; CD97; ADGRE5
Human
HEK293
CD97, a receptor crucial for leukocyte migration, participates in adhesion and signaling during early leukocyte activation. Forming a heterodimer with a large extracellular alpha subunit and a seven-transmembrane beta subunit, CD97 interacts with complement decay-accelerating factor (DAF). The largest isoform (isoform 1) specifically engages with chondroitin sulfate, showcasing its diverse roles in cellular processes. CD97 Protein, Human (HEK293, hFc) is the recombinant human-derived CD97 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD97 Protein, Human (HEK293, hFc) is 378 a.a., with molecular weight of 100-110 kDa.
CD96 promotes adhesive interactions between activated T cells and NK cells in the late stages of the immune response. It promotes the adhesion between NK cells and target cells by interacting with PVR on target cells. CD96 Protein, Human (HEK293, mFc) is the recombinant human-derived CD96 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of CD96 Protein, Human (HEK293, mFc) is 482 a.a., with molecular weight of 120-160 kDa.
CD2 Protein, Human (HEK 293, His) is a transmembrane cell surface glycoprotein found on virtually all T cells, thymocytes, and NK cells. CD2 ligation by CD58 has been shown to mediate T cell adhesion, T cell activation, T cell cytokine production and T cell and NK cells cytotoxic activity.
CD2 Protein mediates T-cell adhesion to other cell types by interacting with CD58 (LFA-3) and CD48/BCM1. Implicated in T-cell triggering, its cytoplasmic domain has signaling functions. CD2 also interacts with CD2AP and PSTPIP1. Moreover, its interaction with FCGR3A modulates NK cell activation and cytotoxicity. CD2 Protein, Cynomolgus (HEK293, C-His) is the recombinant cynomolgus-derived CD2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD2 Protein, Cynomolgus (HEK293, C-His) is 185 a.a., with molecular weight of ~33.91 kDa.
CD5 Protein lacks conserved residue(s) essential for feature annotation propagation. CD5 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived CD5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD5 Protein, Rhesus Macaque (HEK293, His) is 351 a.a., with molecular weight of approximately 41.81 kDa.
CD58, a glycoprotein, is also known as lymphocyte-function antigen 3 (LFA-3). CD58 is a costimulatory receptor, and can interact with its natural ligand (CD2, primarily expressed on the surface of T/NK cells). The CD2-CD58 interaction can promote cell adhesion and recognition, and regulate antiviral responses, inflammatory responses in autoimmune diseases, immune rejection of transplantation, and immune evasion of tumor cells. CD58 Protein, Human (HEK293, His) is the recombinant human-derived CD58 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD58 Protein, Human (HEK293, His) is 187 a.a., with molecular weight of 30-60 kDa.
The CD99 protein is involved in the important T cell adhesion process and helps red blood cells spontaneously form rosettes. It also contributes to the later stages of leukocyte extravasation, helping leukocytes to overcome the endothelial basement membrane during the immune response. CD99 Protein, Human (HEK293, Fc) is the recombinant human-derived CD99 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD99 Protein, Human (HEK293, Fc) is 100 a.a., with molecular weight of ~58.0 kDa.