2. Recombinant Proteins
  3. Enzymes & Regulators
  4. Serine/Threonine Kinase Proteins
  5. Cyclin-Dependent Kinases (CDKs)

Cyclin-Dependent Kinases (CDKs)

Recombinant Protein Expression Service

Cyclin-Dependent Kinases (CDKs)

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70014
    CDK2 Protein, Human (His)

    rHuCyclin-dependent kinase 2/CDK2, His; Cyclin-Dependent Kinase 2; Cell Division Protein Kinase 2; p33 Protein Kinase; CDK2; CDKN2

    		Human E. coli
    CDK2 is an important serine/threonine protein kinase that plays a critical regulatory role in the cell cycle, especially during meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2) and coordinates centrosome duplication and initiation of DNA synthesis at the G1-S transition. CDK2 Protein, Human (His) is the recombinant human-derived CDK2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CDK2 Protein, Human (His) is 298 a.a., with molecular weight of 32-35 kDa.
  • HY-P74257
    CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST)

    Cyclin-dependent kinase 1; CDK1; CDC2; G1/S-specific cyclin-E1; CCNE1

    		Human Sf9 insect cells
    The FGF-9 protein undergoes autoproteolysis and cholesterol attachment in the endoplasmic reticulum. It acts as a morphogen during development, inducing ventral cell fate, participating in limb bud patterning, and aiding in axon guidance. FGF-9 binds to the PTCH1 receptor and activates target gene transcription when in association with SMO, while PTCH1 represses SMO signaling in the absence of FGF-9. CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST) is a recombinant protein dimer complex containing human-derived CDK1-CCNE1 Heterodimer protein, expressed by Sf9 insect cells, with N-10*His, N-GST labeled tag. CDK1-CCNE1 Heterodimer Protein, Human (sf9, His-GST), has molecular weight of ~109.7 (60.4+49.3) kDa.
  • HY-P75668
    CDK1 Protein, Human (sf9, GST)

    Cyclin-dependent kinase 1; CDK1; p34 protein kinase; CDC2; CDC28A; CDKN1; P34CDC2

    		Human Sf9 insect cells
    The CDK1/CDC2-cyclin-B complex is a key regulator in the cell cycle. It plays an important role in cell division and development and regulates a variety of cellular activities, including chromosome segregation, nuclear membrane rupture, cytokinesis, etc. The activity of CDK1 is regulated by a variety of phosphorylation and dephosphorylation, thereby controlling the progression of the cell cycle and the DNA repair process. CDK1 Protein, Human (sf9, GST) is the recombinant human-derived CDK1 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of CDK1 Protein, Human (sf9, GST) is 297 a.a., with molecular weight of ~53 kDa.
  • HY-P72298
    CDK5 Protein, Human (P.pastoris, His)

    Cdk5; Cell division protein kinase 5; Protein kinase CDK5 splicing; PSSALRE

    		Human P. pastoris
    CDK5 is a proline-directed serine/threonine protein kinase that critically regulates neuronal cell cycle, differentiation and potential apoptosis in neuronal diseases by preventing cell cycle re-entry. It interacts with numerous proteins involved in neuronal development and coordinates processes such as survival, migration, differentiation, axonal growth, synaptogenesis, and neurotransmission. CDK5 Protein, Human (P.pastoris, His) is the recombinant human-derived CDK5 protein, expressed by P. pastoris , with N-His labeled tag. The total length of CDK5 Protein, Human (P.pastoris, His) is 292 a.a., with molecular weight of ~38.0 kDa.
  • HY-P700569
    CDK4 Protein, Human (Baculovirus, His)

    CDK4; Cell division protein kinase 4; CMM3; PSK-J3

    		Human Sf9 insect cells
    CDK4 protein, acting as a Ser/Thr kinase in the cyclin D-CDK4 complex, critically regulates the G(1)/S transition by phosphorylating and inhibiting RB family members. This activity, specifically hypophosphorylation of RB1 during early G(1) phase, releases E2F and promotes transcription of genes that drive G(1) progression. CDK4 Protein, Human (Baculovirus, His) is the recombinant human-derived CDK4 protein, expressed by Sf9 insect cells , with N-6*His labeled tag. The total length of CDK4 Protein, Human (Baculovirus, His) is 302 a.a., with molecular weight of 35.6 kDa.
  • HY-P702601
    CDK6 Protein, Human (Sf9, His-Avi)

    Cyclin-dependent kinase 6; Cell division protein kinase 6; CDKN6; EC:2.7.11.22

    		Human Sf9 insect cells
  • HY-P75361
    CDK7&CCNH&MNAT1 Protein, Human (sf9, His)

    CAK1 Protein; CDKN7 Protein; HCAK Protein; MO15 Protein; p39MO15 Protein; STK1 Protein

    		Human Sf9 insect cells
    CDK7, along with regulatory partners CCNH and MNAT1, operates as a crucial serine/threonine kinase in cell cycle regulation and RNA polymerase II-mediated transcription. As the catalytic subunit of the CDK-activating kinase (CAK) complex, CDK7 plays a pivotal role in activating CDK1/cyclin-B and CDK2/cyclins during cell cycle transitions. It phosphorylates key targets, including SPT5/SUPT5H and POLR2A. CDK7, in complex with TFIIH, activates RNA polymerase II for transcript elongation. Its consistent expression and activity contribute to DNA-bound peptide-mediated transcription and cellular growth regulation. CDK7&CCNH&MNAT1 Protein, Human (sf9, His) is the recombinant heterotrimer protein (consiting of CDK7, CCNH, MNAT1), expressed by Sf9 insect cells, with N-His labeled tag. CDK7&CCNH&MNAT1 Protein, Human (sf9, His), has molecular weight of ~25 & 38 & 44 kDa, respectively.
  • HY-P70014A
    CDK2 Protein, Human (N-His)

    rHuCyclin-dependent kinase 2/CDK2, His; Cyclin-Dependent Kinase 2; Cell Division Protein Kinase 2; p33 Protein Kinase; CDK2; CDKN2

    		Human E. coli
    CDK2 is an important serine/threonine protein kinase that plays a critical regulatory role in the cell cycle, especially during meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2) and coordinates centrosome duplication and initiation of DNA synthesis at the G1-S transition. CDK2 Protein, Human (N-His) is the recombinant human-derived CDK2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CDK2 Protein, Human (N-His) is 297 a.a., with molecular weight of approximately 32.65 kDa.
  • HY-P75669
    CDK1 Protein, Mouse (sf9, His-GST)

    Cyclin-dependent kinase 1; CDK1; p34 protein kinase; CDC2; CDC28A; CDKN1; P34CDC2

    		Mouse Sf9 insect cells
    The CDK1 protein centrally controls the eukaryotic cell cycle, coordinating the G2-M transition and mitotic events. It interacts with a variety of cell cycle proteins, phosphorylates a variety of substrates, and affects cell cycle regulation, DNA repair, and apoptosis. CDK1 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CDK1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of CDK1 Protein, Mouse (sf9, His-GST) is 297 a.a., with molecular weight of ~57 kDa.
  • HY-P76247
    CDKL2 Protein, Human (sf9, His)

    Cyclin-dependent kinase-like 2; Protein kinase p56 KKIAMRE; CDKL2

    		Human Sf9 insect cells
  • HY-P701360
    CDK12-CCNK Heterodimer Protein, Human (Sf9)

    CDK12; CCNK; Cyclin-dependent kinase 12; Cdc2-related kinase; arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12; hCDK12; Cyclin-K

    		Human Sf9 insect cells
    The CDK12 protein is a cyclin-dependent kinase that critically phosphorylates the C-terminal domain of POLR2A, thereby regulating transcription elongation. It selectively targets "Ser-5" phosphorylated at "Ser-7" in the CTD repeat and can also target "Ser-2". CDK12-CCNK Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK12-CCNK Heterodimer protein, expressed by Sf9 insect cells , with tag free.
  • HY-P701363
    CDK19-CCNC-MED12 Protein, Human (Sf9)

    CDK19; CCNC; MED12; Cyclin-dependent kinase 19; CDC2-related protein kinase 6; Cell division cycle 2-like protein kinase 6; Cell division protein kinase 19; Cyclin-dependent kinase 11; Death-preventing kinase; Cyclin-C; SRB11 homolog; hSRB11; Mediator of RNA polymerase II transcription subunit 12; Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; Mediator complex subunit 12; OPA-containing protein; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein

    		Human Sf9 insect cells
    CDK19 plays a key role in cellular homeostasis and developmental programming. CDK19 can interact with p53 to inhibit p53-mediated transcription of p21, and regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells. Besides, CDK19 is the paralog of CDK8. CDK8 and CDK19 can cooperate with each other in stimulating NFκB-induced transcription and Dengue virus replication. CDK19-CCNC-MED12 Protein, Human (Sf9) is the recombinant human-derived CDK19-CCNC-MED12 protein, expressed by Sf9 insect cells , with tag free. ,
  • HY-P701364
    CDK3-CCNE1 Heterodimer Protein, Human (Sf9)

    CDK3; CCNE1; Cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1

    		Human Sf9 insect cells
    CDK3 protein is a serine/threonine protein kinase that plays a key role in regulating the eukaryotic cell cycle, especially affecting the G0-G1 and G1-S transitions. It interacts with CCNC/cyclin-C during interphase and phosphorylates substrates such as histone H1, ATF1, RB1, and CABLES1. CDK3-CCNE1 Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK3-CCNE1 Heterodimer protein, expressed by Sf9 insect cells , with tag free.
  • HY-P701365
    CDK3-CCNE1 Heterodimer Protein, Human (Sf9, GST, FLAG, His)

    CDK3; CCNE1; Cyclin-dependent kinase 3; Cell division protein kinase 3; G1/S-specific cyclin-E1

    		Human Sf9 insect cells
    CDK3 protein is a serine/threonine protein kinase that plays a key role in regulating the eukaryotic cell cycle, especially affecting the G0-G1 and G1-S transitions. It interacts with CCNC/cyclin-C during interphase and phosphorylates substrates such as histone H1, ATF1, RB1, and CABLES1. CDK3-CCNE1 Heterodimer Protein, Human (Sf9, GST, FLAG, His) is a recombinant protein dimer complex containing human-derived CDK3-CCNE1 Heterodimer protein, expressed by Sf9 insect cells , with N-6*His, N-Flag, N-GST labeled tag.
  • HY-P701366
    CDK6-CCND1 Heterodimer Protein, Human (Sf9)

    CDK6; CCND1; Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene

    		Human Sf9 insect cells
    The CDK6ic complex is an important serine/threonine protein kinase that regulates cell cycle progression and differentiation, promoting the G1/S transition by phosphorylating substrates such as pRB/RB1 and NPM1. It interacts with D-type G1 cyclins during interphase to form active pRB/RB1 kinase, which controls cell cycle entry. CDK6-CCND1 Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK6-CCND1 Heterodimer protein, expressed by Sf9 insect cells , with tag free.
  • HY-P701368
    CDK6-CCND2 Heterodimer Protein, Human (Sf9, GST, FLAG, His)

    CDK6; CCND2; Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D2

    		Human Sf9 insect cells
    The CDK6ic complex is an important serine/threonine protein kinase that regulates cell cycle progression and differentiation, promoting the G1/S transition by phosphorylating substrates such as pRB/RB1 and NPM1. It interacts with D-type G1 cyclins during interphase to form active pRB/RB1 kinase, which controls cell cycle entry. CDK6-CCND2 Heterodimer Protein, Human (Sf9, GST, FLAG, His) is a recombinant protein dimer complex containing human-derived CDK6-CCND2 Heterodimer protein, expressed by Sf9 insect cells , with N-Flag, N-8*His, N-GST labeled tag.
  • HY-P701369
    CDK6-CCND3 Heterodimer Protein, Human (Sf9)

    CDK6; CCND3; Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D3

    		Human Sf9 insect cells
    The CDK6ic complex is an important serine/threonine protein kinase that regulates cell cycle progression and differentiation, promoting the G1/S transition by phosphorylating substrates such as pRB/RB1 and NPM1. It interacts with D-type G1 cyclins during interphase to form active pRB/RB1 kinase, which controls cell cycle entry. CDK6-CCND3 Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK6-CCND3 Heterodimer protein, expressed by Sf9 insect cells , with tag free.
  • HY-P701370
    CDK6-CCND3 Heterodimer Protein, Human (Sf9, GST, His)

    CDK6; CCND3; Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D3

    		Human Sf9 insect cells
    The CDK6ic complex is an important serine/threonine protein kinase that regulates cell cycle progression and differentiation, promoting the G1/S transition by phosphorylating substrates such as pRB/RB1 and NPM1. It interacts with D-type G1 cyclins during interphase to form active pRB/RB1 kinase, which controls cell cycle entry. CDK6-CCND3 Heterodimer Protein, Human (Sf9, GST, His) is a recombinant protein dimer complex containing human-derived CDK6-CCND3 Heterodimer protein, expressed by Sf9 insect cells , with N-10*His, N-GST labeled tag.
  • HY-P701371
    CDK7-CCNH-MNAT1 Protein, Human (Sf9)

    CDK7; CCNH; MNAT1; Cyclin-dependent kinase 7; 39 kDa protein kinase; p39 Mo15; CDK-activating kinase 1; Cell division protein kinase 7; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit; Cyclin-H; MO15-associated protein; p34; p37; CDK-activating kinase assembly factor MAT1; CDK7/cyclin-H assembly factor; Cyclin-G1-interacting protein; Menage a trois; RING finger protein 66; RING finger protein MAT1; p35; p36

    		Human Sf9 insect cells
    Together with its regulatory partners CCNH and MNAT1, CDK7 functions as an important serine/threonine kinase in cell cycle regulation and RNA polymerase II-mediated transcription. As the catalytic subunit of the CDK-activated kinase (CAK) complex, CDK7 plays a key role in activating CDK1/cyclin-B and CDK2/cyclin during cell cycle transitions. CDK7-CCNH-MNAT1 Protein, Human (Sf9) is the recombinant human-derived CDK7-CCNH-MNAT1 protein, expressed by Sf9 insect cells , with tag free.
  • HY-P701372
    CDK8-CCNC-MED12 Protein, Human (Sf9)

    CDK8; CCNC; MED12; Cyclin-dependent kinase 8; Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35; Cyclin-C; SRB11 homolog; hSRB11; Mediator of RNA polymerase II transcription subunit 12; Activator-recruited cofactor 240 kDa component; ARC240; CAG repeat protein 45; Mediator complex subunit 12; OPA-containing protein; Thyroid hormone receptor-associated protein complex 230 kDa component; Trap230; Trinucleotide repeat-containing gene 11 protein

    		Human Sf9 insect cells
    The CDK8-CCNC-MED12 protein is an important component of the mediator complex, acting as a bridge for gene transcription regulation, transmitting information from gene-specific regulatory factors to RNA polymerase II. It is recruited to the promoter, assembles a preinitiation complex, and promotes transcription. CDK8-CCNC-MED12 Protein, Human (Sf9) is the recombinant human-derived CDK8-CCNC-MED12 protein, expressed by Sf9 insect cells , with tag free.
Cat. No. Product Name Effect Purity