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  3. Cytokines and Growth Factors
  4. Interferon & Receptors
  5. IFN-lambda
  6. IFN-lambda 3/IL-28B

IFN-lambda 3/IL-28B

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IFN-lambda 3 (IL-28B) is a member of the Type-III interferon family. IFN-lambda 3 has high similar 96% sequence identity with IFN-lambda 2 at the amino acid level. IFN-lambda 3 has antiviral antitumour and immunomodulatory activities[1]. IFN-lambda 3 exhibits biological activities through a heterodimeric receptor complex comprising IFNλ receptor 1 (IFNLR1) and IL-10 receptor subunit-β (IL-10RB). When binding to the receptor complex, Jak1 and Tyk2 will be activated, and leads to subsequent tyrosine phosphorylation of the IFN-λR1 (intracellular domain, Tyr406 and Tyr343, Tyr517), and activation of STAT1 and STAT2. Activated STAT1 and STAT2 together with IRF-9 (p48) form a trimeric transcription factor complex (ISGF3). The formed ISGF3 complexes then translocate to the nucleus and promotes the production of IFN-stimulated genes (ISGs) such as IRF7, MX1, and OAS1[2]. Human IFN-lambda 3 shares 61.98% common aa identity with mouse.

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Cat. No. Product Name / Synonyms Species Source
  • HY-P74851
    IFN-lambda 3/IL-28B Protein, Mouse (HEK293, His)

    Interferon lambda-3; IFN-lambda-3; IL-28B; IL-28C; ZCYTO22

    		Mouse HEK293
    IFN-lambda 3 (IL-28B) is a member of the Type-III interferon family. IFN-lambda 3 has high similar 96% sequence identity with IFN-lambda 2 at the amino acid level. IFN-lambda 2 has antiviral antitumour and immunomodulatory activities. IFN-lambda 2 signals through a heterodimeric receptor complex comprising IFNLR1 and IL-10RB. When binding to the receptor complex, Jak1 and Tyk2 will be activated, and leads to tyrosine phosphorylation of the IFN-λR1 and activation of STAT1 and STAT2. Activated STAT1 and STAT2 together with IRF-9 form a trimeric transcription factor complex (ISGF3). The formed ISGF3 then translocate to the nucleus and promotes the production of IFN-stimulated genes (ISGs). IFN-lambda 3/IL-28B Protein, Mouse (HEK293, His) is a recombinant mouse IFN-lambda 3 (M1-V193) with C-terminal His tag, which is expressed in HEK293.
  • HY-P72552
    IFN-lambda 3/IL-28B Protein, Human (HEK293, His)

    Interferon lambda-3; IFN-lambda-3; IL-28B; IL-28C; ZCYTO22

    		Human HEK293
    IFN-lambda 3 (IL-28B) is a member of the Type-III interferon family. IFN-lambda 3 has high similar 96% sequence identity with IFN-lambda 2 at the amino acid level. IFN-lambda 2 has antiviral antitumour and immunomodulatory activities. IFN-lambda 2 signals through a heterodimeric receptor complex comprising IFNLR1 and IL-10RB. When binding to the receptor complex, Jak1 and Tyk2 will be activated, and leads to tyrosine phosphorylation of the IFN-λR1 and activation of STAT1 and STAT2. Activated STAT1 and STAT2 together with IRF-9 form a trimeric transcription factor complex (ISGF3). The formed ISGF3 then translocate to the nucleus and promotes the production of IFN-stimulated genes (ISGs). IFN-lambda 3/IL-28B Protein, Human (HEK293, His) is a recombinant human IFN-lambda 3 (V22-V196) with C-terminal 6*His tag, which is expressed in HEK293.
  • HY-P700120AF
    Animal-Free IFN-lambda 3/IL-28B Protein, Human (His)

    Interferon lambda-3; IFN-lambda-3; IL-28B; IL-28C; ZCYTO22

    		Human E. coli
    The IFN-lambda 3/IL-28B protein is a multifaceted cytokine with antiviral, antitumor, and immunomodulatory activities that plays a key role in antiviral host defense, particularly within epithelial tissues. Animal-Free IFN-lambda 3/IL-28B Protein, Human (His) is the recombinant human-derived animal-FreeIFN-lambda 3/IL-28B protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IFN-lambda 3/IL-28B Protein, Human (His) is 175 a.a., with molecular weight of ~25.57 kDa.
  • HY-P700204AF
    Animal-Free IFN-lambda 3/IL-28B Protein, Mouse (His)

    IFN-λ3; IFL-1; INF-l; Interferon lambda-3; IFN-lambda-3; IL-28B; Ifnl3

    		Mouse E. coli
    The IFN-lambda 3/IL-28B protein is a cytokine with antiviral, antitumor, and immunomodulatory properties that is critical for defense against viruses, especially in epithelial tissues. It acts as a ligand for IL10RB and IFNLR1 receptor complexes, activating the JAK/STAT signaling pathway and inducing IFN-stimulated genes (ISG) into an antiviral state. Animal-Free IFN-lambda 3/IL-28B Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIFN-lambda 3/IL-28B protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IFN-lambda 3/IL-28B Protein, Mouse (His) is 164 a.a., with molecular weight of ~20.56 kDa.
  • HY-P73201
    IFN-lambda 3/IL-28B Protein, Human (P.pastoris, His)

    Interferon lambda-3; IFN-lambda-3; IL-28B; IL-28C; ZCYTO22

    		Human P. pastoris
    IFN-lambda 3 (IL-28B) is a member of the Type-III interferon family. IFN-lambda 3 has high similar 96% sequence identity with IFN-lambda 2 at the amino acid level. IFN-lambda 2 has antiviral antitumour and immunomodulatory activities. IFN-lambda 2 signals through a heterodimeric receptor complex comprising IFNLR1 and IL-10RB. When binding to the receptor complex, Jak1 and Tyk2 will be activated, and leads to tyrosine phosphorylation of the IFN-λR1 and activation of STAT1 and STAT2. Activated STAT1 and STAT2 together with IRF-9 form a trimeric transcription factor complex (ISGF3). The formed ISGF3 then translocate to the nucleus and promotes the production of IFN-stimulated genes (ISGs). IFN-lambda 3/IL-28B Protein, Human (P.pastoris, His) is a recombinant human IFN-lambda 3 (V18-V196) with C-terminal His tag, which is expressed in P.pastoris.
Cat. No. Product Name Effect Purity