2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. IL-35

IL-35

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70338
    IL-35 Protein, Human (HEK293, Fc)

    rHuInterleukin 35/IL-35, Fc; Interleukin 35; IL35; hIL35

    		Human HEK293
    IL-35 protein plays a key role in immune regulation, forming IL-12 cytokine with IL12B or IL-35 cytokine with EBI3/IL27B. IL-12 modulates T cell and natural killer cell responses and induces interferon gamma production. IL-35 Protein, Human (HEK293, Fc) is a recombinant protein dimer complex containing human-derived IL-35 protein, expressed by HEK293 , with C-hFc labeled tag. IL-35 Protein, Human (HEK293, Fc), has molecular weight of 80-120 kDa.
  • HY-P73882
    IL-35 Protein, Human (HEK293, His-hFc-Myc)

    CLMF; IL-12A; IL-35; Interleukin-35; NFSK; NKSF1; P35

    		Human HEK293
    IL-35 Protein plays a pivotal role in immune regulation, forming the IL-12 cytokine with IL12B or the IL-35 cytokine with EBI3/IL27B. IL-12 regulates T-cell and natural killer-cell responses, inducing interferon-gamma production. IL-35 contributes significantly to maintaining immune homeostasis in the liver, acting as an immune-suppressive cytokine. Mechanistically, IL-12 exerts effects through the IL12R1 and IL12R2 receptor subunits, phosphorylating cellular substrates and regulating cytokine-responsive genes via phosphorylated STAT4. In the IL-35 context, unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers mediate signaling, requiring transcription factors STAT1 and STAT4. IL-35 interacts with NBR1, promoting IL-12 secretion, and the IL-35 heterodimer with EBI3/IL27B is non-disulfide-linked, distinguishing it from IL-12. IL-35 Protein, Human (HEK293, His-hFc-Myc) is a recombinant protein dimer complex containing human-derived IL-35 protein, expressed by HEK293, with C-hFc, C-Flag, C-8*His labeled tag. IL-35 Protein, Human (HEK293, His-hFc-Myc), has molecular weight of ~60 & 63 kDa, respectively.
  • HY-P73880
    IL-35 Protein, Human (HEK293, Flag-His)

    CLMF; IL-12A; IL-35; Interleukin-35; NFSK; NKSF1; P35

    		Human HEK293
    IL-35 Protein plays a pivotal role in immune regulation, forming the IL-12 cytokine with IL12B or the IL-35 cytokine with EBI3/IL27B. IL-12 regulates T-cell and natural killer-cell responses, inducing interferon-gamma production. IL-35 contributes significantly to maintaining immune homeostasis in the liver, acting as an immune-suppressive cytokine. Mechanistically, IL-12 exerts effects through the IL12R1 and IL12R2 receptor subunits, phosphorylating cellular substrates and regulating cytokine-responsive genes via phosphorylated STAT4. In the IL-35 context, unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers mediate signaling, requiring transcription factors STAT1 and STAT4. IL-35 interacts with NBR1, promoting IL-12 secretion, and the IL-35 heterodimer with EBI3/IL27B is non-disulfide-linked, distinguishing it from IL-12. IL-35 Protein, Human (HEK293, Flag-His) is a recombinant protein dimer complex containing human-derived IL-35 protein, expressed by HEK293, with C-His, C-Flag labeled tag. IL-35 Protein, Human (HEK293, Flag-His), has molecular weight of ~48.3 kDa.
Cat. No. Product Name Effect Purity