2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial Endogenous Metabolite
  4. PRRSV/CD163-IN-1

PRRSV/CD163-IN-1 is a PRRSV/CD163 inhibitor. PRRSV/CD163-IN-1 can inhibit the interaction between the PRRSV glycoprotein (GP2a or GP4) and the CD163-SRCR5 domain. PRRSV/CD163-IN-1 can be used for the research of porcine reproductive and respiratory syndrome (PRRS) .

For research use only. We do not sell to patients.

PRRSV/CD163-IN-1 Chemical Structure

PRRSV/CD163-IN-1 Chemical Structure

CAS No. : 560995-89-3

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
5 mg USD 350 In-stock
10 mg USD 580 In-stock
25 mg USD 1100 In-stock
50 mg USD 1700 In-stock
100 mg USD 2680 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

PRRSV/CD163-IN-1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PRRSV/CD163-IN-1 is a PRRSV/CD163 inhibitor. PRRSV/CD163-IN-1 can inhibit the interaction between the PRRSV glycoprotein (GP2a or GP4) and the CD163-SRCR5 domain. PRRSV/CD163-IN-1 can be used for the research of porcine reproductive and respiratory syndrome (PRRS) [1].

In Vitro

PRRSV/CD163-IN-1 (Compound B7) (5 μM) inhibits the Protein-protein interaction (PPI) between PRRSV GP4 glycoprotein and CD163-SRCR5 domain[1].
PRRSV/CD163-IN-1 (24 h) is well-tolerated by PAMs at concentrations below 25 μM, with the LC50 value of 81.7 μM[1].
PRRSV/CD163-IN-1 (0, 5, 10, 15, or 20 μM; 4 h) inhibits PRRSV infection of PAMs in a dose-dependent manner[1].
PRRSV/CD163-IN-1 (15 μM) significantly inhibits the infection caused by both type I and type II PRRSV strains[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PRRSV/CD163-IN-1 Related Antibodies

RT-PCR[1]

Cell Line: Porcine alveolar macrophages (PAMs)
Concentration: 0, 5, 10, 15, or 20 μM
Incubation Time: 4 h
Result: Revealed a dose-dependent inhibition of PRRSV infection of PAMs.
Molecular Weight

557.62

Formula

C25H24FN5O5S2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(NC1=NC2=C(N=C1NC3=CC=CC(S(=O)(N4CCOCC4)=O)=C3)C=CC=C2)(C5=CC=C(C=C5C)F)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (89.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7933 mL 8.9667 mL 17.9334 mL
5 mM 0.3587 mL 1.7933 mL 3.5867 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7933 mL 8.9667 mL 17.9334 mL 44.8334 mL
5 mM 0.3587 mL 1.7933 mL 3.5867 mL 8.9667 mL
10 mM 0.1793 mL 0.8967 mL 1.7933 mL 4.4833 mL
15 mM 0.1196 mL 0.5978 mL 1.1956 mL 2.9889 mL
20 mM 0.0897 mL 0.4483 mL 0.8967 mL 2.2417 mL
25 mM 0.0717 mL 0.3587 mL 0.7173 mL 1.7933 mL
30 mM 0.0598 mL 0.2989 mL 0.5978 mL 1.4944 mL
40 mM 0.0448 mL 0.2242 mL 0.4483 mL 1.1208 mL
50 mM 0.0359 mL 0.1793 mL 0.3587 mL 0.8967 mL
60 mM 0.0299 mL 0.1494 mL 0.2989 mL 0.7472 mL
80 mM 0.0224 mL 0.1121 mL 0.2242 mL 0.5604 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PRRSV/CD163-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRRSV/CD163-IN-1560995-89-3BacterialEndogenous MetabolitePorcine reproductive and respiratory syndrome (PRRS)PRRSV infectionporcine alveolar macrophages (PAMs)Protein-protein interaction (PPI)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PRRSV/CD163-IN-1
Cat. No.:
HY-147089
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.