PTAC oxalate

Cat. No.: HY-107656: FAQs
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PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (K_i values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects.

For research use only. We do not sell to patients.

PTAC oxalate Chemical Structure

CAS No. : 201939-40-4

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Description

IC₅₀ & Target^[1]^[2]

mAChR1

0.6 nM (Ki)

mAChR2

2.8 nM (Ki)

mAChR3

0.2 nM (Ki)

mAChR4

0.2 nM (Ki)

mAChR5

0.8 nM (Ki)

In Vivo

PTAC oxalate (0.01, 0.05 mg/kg; IP) alleviates the mechanical allodynia in 0.05 mg/kg. PTAC oxalate decreases the immobility time of mice from both the sham and nerve injury groups at the dose of 0.05 mg/kg, but not at the dose of 0.01 mg/kg^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mouse model of neuropathic pain^[2]
Dosage:	0.01, 0.05 mg/kg
Administration:	IP
Result:	The mechanical allodynia was alleviated with 0.05 mg/kg. At 0.05 mg/kg increased the paw withdrawal thresholds (PWTs) of the nerve-injury groups injected at day 4 after nerve injury. At 0.01 mg/kg had no effect on the PWTs in the sham and nerve-injury groups injected at day 14 after nerve injury.

Molecular Weight

359.46

Formula

C₁₄H₂₁N₃O₄S₂

CAS No.

201939-40-4

SMILES

CCCSC1=NSN=C1[C@@H]2[C@@H]3C[N@@](CCC3)C2.OC(C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. F P Bymaster, et al. Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane. Eur J Pharmacol. 1998 Sep 4;356(2-3):109-19. [Content Brief]

[2]. (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain. Anesth Analg. 2017 Apr;124(4):1330-1338. [Content Brief]

PTAC oxalate Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTAC201939-40-4mAChRMuscarinic acetylcholine receptorMuscarinicmechanicalallodynianeuropathic painantidepressionInhibitorinhibitorinhibit

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