1. Metabolic Enzyme/Protease
  2. Phosphatase
  3. PTP1B-IN-18

PTP1B-IN-18 is an orally active complete mixed type protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 35.2 μM. PTP1B-IN-18 can be used for type 2 diabetes research.

For research use only. We do not sell to patients.

PTP1B-IN-18 Chemical Structure

PTP1B-IN-18 Chemical Structure

CAS No. : 2848581-84-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PTP1B-IN-18 is an orally active complete mixed type protein tyrosine phosphatase 1B (PTP1B) inhibitor with a Ki of 35.2 μM. PTP1B-IN-18 can be used for type 2 diabetes research[1].

IC50 & Target

ki: 35.2 μM (PTP1B)[1]

In Vivo

PTP1B-IN-18 (Compound 44; 100 mg/kg; p.o.; single administration) reduces 23% of the blood sugar level[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Wistar rats weighing 200-250 g (type 2 diabetic rat model)[1]
Dosage: 100 mg/kg
Administration: Oral administration; single administration
Result: Showed hypoglycemic effect under physiological conditions.
Molecular Weight

469.51

Formula

C26H19N3O4S

CAS No.
SMILES

O=C(NC1=CC=C(C=C1)C(O)=O)CSC2=NC3=C(N2)C=CC(OC4=CC=C5C=CC=CC5=C4)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PTP1B-IN-18 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PTP1B-IN-18
Cat. No.:
HY-144717
Quantity:
MCE Japan Authorized Agent: