2. Apoptosis Autophagy Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Autophagy Reactive Oxygen Species
  4. Pyridinium bisretinoid A2E TFA

Pyridinium bisretinoid A2E TFA  (Synonyms: A2E TFA)

Cat. No.: HY-134928A
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Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases.

For research use only. We do not sell to patients.

Pyridinium bisretinoid A2E TFA Chemical Structure

Pyridinium bisretinoid A2E TFA Chemical Structure

CAS No. : 1821308-73-9

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1 mg USD 380 In-stock
5 mg USD 820 In-stock
10 mg USD 1320 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Pyridinium bisretinoid A2E TFA:

Pyridinium bisretinoid A2E TFA Related Antibodies

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Description

Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases[1][2].

In Vitro

Exposure of Pyridinium bisretinoid A2E (A2E) to light triggers its conversion into at least two products. One of these is epoxy-A2E, which is hydrophilic and can be transferred from the membrane to an aqueous solution. The other product is an unidentified hydrophobic substance[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyridinium bisretinoid A2E TFA Related Antibodies
Molecular Weight

705.93

Formula

C44H58F3NO3
CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

OCC[N+]1=CC=C(/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C=C1/C=C(C)/C=C/C=C(C)/C=C/C3=C(C)CCCC3(C)C.O=C([O-])C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (141.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4166 mL 7.0829 mL 14.1657 mL
5 mM 0.2833 mL 1.4166 mL 2.8331 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: ≥90.0%

COA (245 KB) HNMR (298 KB) CNMR (284 KB) MS (232 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4166 mL 7.0829 mL 14.1657 mL 35.4143 mL
5 mM 0.2833 mL 1.4166 mL 2.8331 mL 7.0829 mL
10 mM 0.1417 mL 0.7083 mL 1.4166 mL 3.5414 mL
15 mM 0.0944 mL 0.4722 mL 0.9444 mL 2.3610 mL
20 mM 0.0708 mL 0.3541 mL 0.7083 mL 1.7707 mL
25 mM 0.0567 mL 0.2833 mL 0.5666 mL 1.4166 mL
30 mM 0.0472 mL 0.2361 mL 0.4722 mL 1.1805 mL
40 mM 0.0354 mL 0.1771 mL 0.3541 mL 0.8854 mL
50 mM 0.0283 mL 0.1417 mL 0.2833 mL 0.7083 mL
60 mM 0.0236 mL 0.1180 mL 0.2361 mL 0.5902 mL
80 mM 0.0177 mL 0.0885 mL 0.1771 mL 0.4427 mL
100 mM 0.0142 mL 0.0708 mL 0.1417 mL 0.3541 mL
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Pyridinium bisretinoid A2E TFA Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyridinium bisretinoid A2E1821308-73-9A2EApoptosisAutophagyReactive Oxygen SpeciesROSblue-lightPhotoactivationInhibitorinhibitorinhibit

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