Annexin A5/ANXA5 Protein, Mouse (His, Myc)

The annexin A5 (ANXA5) protein acts as an anticoagulant, indirectly inhibiting the thromboplastin-specific complex, which is critical in the coagulation cascade. As a monomer, ANXA5 plays a key role in regulating the coagulation pathway, affecting the delicate balance between pro- and anti-coagulant factors. Annexin A5/ANXA5 Protein, Mouse (His, Myc) is the recombinant mouse-derived Annexin A5/ANXA5 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of Annexin A5/ANXA5 Protein, Mouse (His, Myc) is 318 a.a., with molecular weight of 43.2 kDa.

Annexin A5 (ANXA5) protein serves as an anticoagulant, acting as an indirect inhibitor of the thromboplastin-specific complex crucial in the blood coagulation cascade. Structurally, it exists as a monomer, and in its functional capacity, ANXA5 plays a pivotal role in regulating key components of the coagulation pathway, thereby influencing the delicate balance between procoagulant and anticoagulant factors. Additionally, ANXA5 exhibits binding interactions with ATRX and EIF5B, suggesting its involvement in diverse cellular processes beyond its role in coagulation. These multifaceted attributes underscore the significance of ANXA5 in cellular regulation and its potential implications in both hemostasis and broader cellular functions.

Mouse

E. coli

N-10*His;C-Myc

P48036 (A2-D319)

11747

43.2 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.