CFHR2 Protein, Human (HEK293, His)

CFHR2, a key complement regulator, competently rivals CFH by avidly interacting with tissue-bound complement fragments. It also associates with lipoproteins, hinting at a role in lipid metabolism. With a distinctive head-to-tail homodimeric structure, CFHR2 forms heterodimers with CFHR1 or CFHR5, showcasing its versatile involvement in the regulatory dynamics of the complement system. CFHR2 Protein, Human (HEK293, His) is the recombinant human-derived CFHR2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CFHR2 Protein, Human (HEK293, His) is 252 a.a., with molecular weight of 31 & (33-36) kDa, respectively.

CFHR2 takes center stage in the intricate landscape of complement regulation. Functioning as a crucial player, it engages in avid interactions with tissue-bound complement fragments, showcasing its ability to competently rival the physiological complement inhibitor CFH. Moreover, CFHR2 demonstrates a propensity to associate with lipoproteins, suggesting a potential involvement in lipid metabolism. Adding to its complexity, CFHR2 exhibits a distinctive head-to-tail homodimeric structure and forms heterodimers with CFHR1 or CFHR5, underscoring its versatile role in the regulatory ballet of the complement system.

Human

HEK293

C-6*His

P36980 (E19-K270)

3080  [NCBI]

EAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSCEEK

31&(33-36) kDa

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 200 mM NaCl, 2 mM EDTA, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.