Coagulation Factor III/F3 Protein, Canine (HEK293, His)

Coagulation Factor III (F3), or Tissue Factor (TF), initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex critically activates factors IX or X through limited proteolysis, initiating the coagulation cascade on the cell surface. F3's interaction with HSPE, inhibited by heparin, promotes the generation of activated factor X, emphasizing its central role in regulating hemostatic processes. Coagulation Factor III/F3 Protein, Canine (HEK293, His) is the recombinant canine-derived Coagulation Factor III/F3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Coagulation Factor III/F3 Protein, Canine (HEK293, His) is 214 a.a., with molecular weight of 35-45 kDa.

Coagulation Factor III (F3), also known as Tissue Factor (TF), serves as a pivotal initiator of blood coagulation through the formation of a complex with circulating factor VII or VIIa. This [TF:VIIa] complex plays a critical role in activating factors IX or X through specific limited proteolysis, thereby initiating the assembly and propagation of the coagulation protease cascade on the cell surface. Notably, F3 interacts with HSPE, and heparin inhibits this interaction. The interplay between F3 and HSPE promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII, emphasizing F3's central involvement in the regulation of hemostatic processes.

Canine

HEK293

C-His

Q4W6L5 (T35-E248)

490153  [NCBI]

35-45 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.