Hemagglutinin neuraminidase/HN Protein, Mumps virus strain RW (Cell-Free, His)

Hemagglutinin neuraminidase (HN) Protein is pivotal in viral infection, attaching the virus to sialic acid-containing cell receptors, initiating infection. Its binding induces a conformational change enabling the F protein to trigger virion-cell membrane fusion, facilitating virus entry. HN Protein's neuraminidase activity ensures efficient virus spread by dissociating mature virions from glycoproteins containing neuraminic acid. Hemagglutinin neuraminidase/HN Protein, Mumps virus strain RW (Cell-Free, His) is the recombinant Virus-derived Hemagglutinin neuraminidase/HN protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of Hemagglutinin neuraminidase/HN Protein, Mumps virus strain RW (Cell-Free, His) is 582 a.a., with molecular weight of 65.6 kDa.

The Hemagglutinin neuraminidase (HN) protein plays a crucial role in viral infection by attaching the virus to cell receptors that contain sialic acid, initiating the infection process. When the HN protein binds to the receptor, it induces a conformational change that enables the F protein to trigger fusion between the virus and the cell membranes, facilitating the entry of the virus into the host cell. Additionally, the HN protein exhibits neuraminidase activity, which ensures the efficient spread of the virus by dissociating the mature virions from glycoproteins containing neuraminic acid.

Virus

E. coli Cell-free

N-10*His

P10866 (M1-T582)

/

MEPSKLFTISDNATFAPGPVNNAADKKTFRTCFRILVLSVQAVTLILVIVTLGELVRMINDQGLSNQLSSITDKIRESATMIASAVGVMNQVIHGVTVSLPLQIEGNQNQLLSTLATICTSKKQISNCSTNIPLVNDLRFINGINKFIIEDYANHDFSIGHPLNMPSFIPTATSPNGCTRIPSFSLGKTHWCYTHNVINANCKDHTSSNQYVSMGILVQTASGYPMFKTLKIQYLSDGLNRKSCSIATVPDGCAMYCYVSTQLETDDYAGSSPPTQKLTLLFYNDTVTERTISPSGLEGNWATLVPGVGSGIYFENKLIFPAYGGVLPNSTLGVKLAREFFRPVNPYNPCSGPQQDLDQRALRSYFPSYLSNRRVQSAFLVCAWNQILVTNCELVVPSNNQTLMGAEGRVLLINNRLLYYQRSTSWWPYELLYEISFTFTNSGQSSVNMSWIPIYSFTRPGSGKCSGENVCPIACVSGVYLDPWPLTPYSHQSGINRNFYFTGALLNSSTTRVNPTLYVSALNNLKVLAPYGTQGLSASYTTTTCFQDTGDASVYCVYIMELASNIVGEFQILPVLTRLTIT

65.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.