IGFBP-3R Protein, Mouse (HEK293, Fc)

The IGFBP-3R protein was identified as an IGFBP3-specific cell death receptor and becomes a potential mediator of caspase-8-dependent apoptosis upon ligand binding. This receptor actively interacts with IGFBP3, forming a key molecular connection that may initiate the apoptotic signaling cascade. IGFBP-3R Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IGFBP-3R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IGFBP-3R Protein, Mouse (HEK293, Fc) is 166 a.a., with molecular weight of 60-70 kDa.

IGFBP-3R, a cell death receptor specific for insulin-like growth factor binding protein 3 (IGFBP3), is implicated in mediating caspase-8-dependent apoptosis upon ligand binding. This receptor interacts directly with IGFBP3, suggesting a key role in transducing signals related to cell survival and death pathways. The binding of IGFBP3 to IGFBP-3R may trigger apoptotic cascades, potentially involving caspase-8. This interaction between IGFBP-3R and caspase-8 underscores the potential involvement of this receptor in regulating apoptotic processes.

Mouse

HEK293

C-hFc

Q9D123 (G39-R204)

68742  [NCBI]

60-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.