MAPK4 Protein, Human (Sf9, His, GST)

MAPK4, an atypical MAPK protein, phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5, forming a complex with intricate phosphorylation events. Interaction with MAPKAPK5 leads to ERK3/MAPK6 phosphorylation at Ser-189, activating MAPKAPK5, which reciprocally phosphorylates ERK3/MAPK6. The specific cellular role of this interplay, while unclear, suggests ERK3's potential involvement in promoting entry into the cell cycle. MAPK4 Protein, Human (Sf9, His, GST) is the recombinant human-derived MAPK4 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of MAPK4 Protein, Human (Sf9, His, GST) is 586 a.a., .

ERK3, an atypical MAPK protein, displays distinct kinase activity by phosphorylating microtubule-associated protein 2 (MAP2) and MAPKAPK5. The functional significance of the complex formed with MAPKAPK5 is not fully elucidated, but it involves a intricate series of phosphorylation events. Upon interaction with the atypical MAPKAPK5, ERK3/MAPK6 undergoes phosphorylation at Ser-189 and subsequently facilitates the phosphorylation and activation of MAPKAPK5. Intriguingly, MAPKAPK5 reciprocally phosphorylates ERK3/MAPK6. The specific role of this interplay in cellular processes remains unclear, although it is suggested that ERK3 may play a role in promoting entry into the cell cycle.

Human

Sf9 insect cells

N-8*His;N-GST

P31152 (A2-W587)

5596

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.