PAK6 Protein, Human (His)

PAK6, a dynamic serine/threonine kinase, regulates gene transcription activated by AR or MAP2K6/MAPKK6. It phosphorylates and inhibits AR-mediated transcription, hindering ESR1-mediated transcription. PAK6 interacts with IQGAP1, suggesting a role in cytoskeleton regulation. Moreover, it protects cells from apoptosis by phosphorylating BAD, showcasing its multifaceted impact on transcriptional control and cytoskeletal dynamics. PAK6 Protein, Human (His) is the recombinant human-derived PAK6 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PAK6 Protein, Human (His) is 292 a.a., .

PAK6, a serine/threonine protein kinase, serves as a regulator of gene transcription, with its kinase activity triggered by various effectors, including AR or MAP2K6/MAPKK6. Notably, it phosphorylates the DNA-binding domain of the androgen receptor/AR, hindering AR-mediated transcription, and also inhibits ESR1-mediated transcription. PAK6's involvement in cytoskeleton regulation is suggested by its interaction with IQGAP1. Additionally, PAK6 demonstrates a potential role in cell survival by protecting cells from apoptosis through the phosphorylation of BAD. This multifaceted kinase exhibits a regulatory impact on key cellular processes, showcasing its significance in transcriptional control and cytoskeletal dynamics.

Human

E. coli

N-6*His

Q9NQU5 (G383-Y674)

106821730

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.