PRDX1 Protein, Mouse (His)

The PRDX1 protein is a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols. Its key role in cellular protection against oxidative stress includes detoxifying superoxide and acting as a sensor of hydrogen peroxide-mediated signaling events. PRDX1 Protein, Mouse (His) is the recombinant mouse-derived PRDX1 protein, expressed by E. coli , with C-His labeled tag. The total length of PRDX1 Protein, Mouse (His) is 199 a.a., with molecular weight of ~27 kDa.

PRDX1, a thiol-specific peroxidase, functions as a catalyst for the reduction of hydrogen peroxide and organic hydroperoxides, converting them into water and alcohols, respectively. Its pivotal role in cell protection against oxidative stress involves detoxifying peroxides and acting as a sensor for hydrogen peroxide-mediated signaling events. Additionally, PRDX1 may contribute to the signaling cascades initiated by growth factors and tumor necrosis factor-alpha, exerting control over intracellular H(2)O(2) concentrations. Notably, PRDX1 exhibits the ability to reduce an intramolecular disulfide bond in GDPD5, thereby modulating GDPD5's capacity to drive postmitotic motor neuron differentiation. These diverse functions underscore the versatile and intricate regulatory roles of PRDX1 in cellular processes associated with redox signaling and differentiation.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Mouse

E. coli

C-His

P35700 (M1-K199)

18477  [NCBI]

Approximately 27 kDa

Greater than 85% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of PBS, 10% glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.