SLC1A2 Protein, Human (Sf9, His, MBP, FLAG)

The SLC1A2 protein is a sodium-dependent high-affinity amino acid transporter that greatly promotes the uptake of L-glutamic acid, L-aspartate, and D-aspartate. As an symporter, it co-transports an amino acid molecule with two or three Na(+) ions and a proton, while counter-transporting a K(+) ion. SLC1A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC1A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC1A2 Protein, Human (Sf9, His, MBP, FLAG) is 574 a.a., .

SLC1A2, a sodium-dependent, high-affinity amino acid transporter, plays a crucial role in the uptake of L-glutamate, L-aspartate, and D-aspartate. Operating as a symporter, this transporter facilitates the co-transport of one amino acid molecule with two or three Na(+) ions and one proton, concomitant with the counter-transport of one K(+) ion. Additionally, SLC1A2 mediates Cl(-) flux, decoupled from amino acid transport, preventing the accumulation of negative charges resulting from aspartate and Na(+) symport. This dual functionality is integral to its role in swiftly removing released glutamate from the synaptic cleft, thereby contributing to the prompt termination of the postsynaptic action of glutamate. The transporter's high-affinity and sodium-dependent mechanism underscore its significance in regulating neurotransmission and maintaining synaptic homeostasis.

Human

Sf9 insect cells

N-MBP;C-Flag;N-8*His

P43004 (M1-K574)

6506

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.