TRPC1 Protein, Mouse (Cell-Free, His)

The TRPC1 protein theoretically forms a receptor-activated nonselective calcium-permeable cation channel that may be regulated by a phosphatidylinositol second messenger system activated through receptor tyrosine kinases or G protein-coupled receptors. It may also respond to depletion of intracellular calcium stores. TRPC1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived TRPC1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of TRPC1 Protein, Mouse (Cell-Free, His) is 793 a.a., with molecular weight of 94.0 kDa.

TRPC1 protein is postulated to assemble into a receptor-activated non-selective calcium-permeant cation channel, likely operated by a phosphatidylinositol second messenger system activated through receptor tyrosine kinases or G-protein coupled receptors. Additionally, it appears to be activated by the depletion of intracellular calcium stores. TRPC1 can form homotetramers and heterotetramers with TRPC4 and/or TRPC5, highlighting its potential to engage in diverse channel configurations. It interacts with TRPC4, TRPC5, and ITPR3, suggesting a network of associations with other proteins involved in calcium signaling. Furthermore, TRPC1 interacts with MX1, RNF24, FKBP4, and TRPC4AP, indicating its involvement in various cellular processes. Notably, TRPC1 interacts with PLSCR1, implicating its potential role in calcium-dependent phosphatidylserine externalization and apoptosis, further underlining its multifaceted contributions to cellular signaling and protein interactions.

Mouse

E. coli Cell-free

N-10*His

Q61056 (M1-N793)

22063

MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEENTLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQLLLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDVAPVILAAHRNNYEILTMLLKQDVSLPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYRCLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQARNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTVWFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGASYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDFLEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVLSYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSKEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN

94.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.