2. TGF-beta/Smad
  3. TGF-β Receptor
  4. RepSox

RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor.

For research use only. We do not sell to patients.

RepSox Chemical Structure

RepSox Chemical Structure

CAS No. : 446859-33-2

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Based on 1 publication(s) in Google Scholar

Other Forms of RepSox:

RepSox Related Antibodies

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Description

RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor[1].

IC50 & Target

IC50: ALK5 autophosphorylation (4 nM)
In Vitro

RepSox (GMP) (10 μM) induces MEFs differentiating to chemically induced pluripotent stem cells (CiPSCs)[1].
RepSox (GMP) (10 μM, in stage I-Stage III induction medium) induces hCiPS cells from HEFs[2].
RepSox (GMP) together with Forskolin (HY-15371) increases the number of proliferative cells in MEFs expressing MyoD, confirmed by increased EdU incorporation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RepSox Related Antibodies
Molecular Weight

287.32

Formula

C17H13N5
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RepSox Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RepSox (GMP)446859-33-2E-616452 (GMP) SJN 2511 (GMP)TGF-β ReceptorTransforming growth factor beta receptorsTGF-β ALK5autophosphorylationobesitymetabolictype 2 diabetesreprogramdifferentiatingpluripotent stem cellPSCInhibitorinhibitorinhibit

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HY-13012G
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