Rezafungin (Synonyms: Biafungin; CD101; SP-3025)

Cat. No.: HY-108009: FAQs
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Rezafungin (Biafungin) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp..

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Rezafungin acetate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Rezafungin Chemical Structure

CAS No. : 1396640-59-7

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Other In-stock Forms of Rezafungin:

Other Forms of Rezafungin:

Rezafungin acetate In-stock

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Description

In Vivo

Rezafungin (Biafungin) shows potent in vivo efficacy as prophylaxis against Pneumocystis in a mouse infection model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C3H/HeN mice^[1]
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; once daily for 6 days
Result:	Significantly reduced nuclei and asci burdens.

Clinical Trial

Molecular Weight

1226.39

Formula

C₆₃H₈₅N₈O₁₇

CAS No.

1396640-59-7

SMILES

O=C1N2[C@]([C@@H](O)[C@@H](C)C2)([H])C(N[C@]([C@@H](C[C@@H](C(N[C@]([C@H](O)C)([H])C(N3[C@](C[C@@H](O)C3)([H])C(N[C@]([C@H](O)[C@H](C4=CC=C(O)C=C4)O)([H])C(N[C@@]1([H])[C@H](O)C)=O)=O)=O)=O)NC(C5=CC=C(C6=CC=C(C7=CC=C(OCCCCC)C=C7)C=C6)C=C5)=O)O)([H])OCC[N+](C)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Melanie Cushion, et al. Rezafungin Prophylactic Efficacy in a Mouse Model of Pneumocystis Pneumonia. VOLUME 25, ISSUE 3, SUPPLEMENT, S366, MARCH 01, 2019.

[2]. Sofjan AK, et al. Rezafungin (CD101), a next-generation echinocandin: A systematic literature review and assessment of possible place in therapy. J Glob Antimicrob Resist. 2018 Sep;14:58-64. [Content Brief]

Rezafungin Related Classifications

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Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rezafungin1396640-59-7Biafungin CD101 SP-3025CD101CD 101CD-101SP3025SP 3025SP-3025Fungallong-lastingechinocandinantifungalinfectionInhibitorinhibitorinhibit

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