2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. Ritlecitinib (malonate)

Ritlecitinib (malonate)  (Synonyms: PF-06651600 (malonate))

Cat. No.: HY-100754A
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Ritlecitinib (PF-06651600) malonate is an orally active and selective JAK3 inhibitor with an IC50 of 33.1 nM. Ritlecitinib (malonate) can be used for the research of inflammatory and autoimmune diseases.

For research use only. We do not sell to patients.

Ritlecitinib (malonate) Chemical Structure

Ritlecitinib (malonate) Chemical Structure

CAS No. : 2140301-97-7

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Description

Ritlecitinib (PF-06651600) malonate is an orally active and selective JAK3 inhibitor with an IC50 of 33.1 nM. Ritlecitinib (malonate) can be used for the research of inflammatory and autoimmune diseases[1].

IC50 & Target

IC50: 33.1 nM (JAK3)[1]
Molecular Weight

389.41

Formula

C18H23N5O5
CAS No.
SMILES

OC(CC(O)=O)=O.C=CC(N1[C@@H](C)CC[C@@H](NC2=C3C(NC=C3)=NC=N2)C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ritlecitinib (malonate) Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ritlecitinib (malonate)2140301-97-7PF-06651600 (malonate)JAKJanus kinaseJAK3inflammatoryautoimmune diseasesInhibitorinhibitorinhibit

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