(S)-1-Benzylpyrrolidin-3-ol

Name: (S)-1-Benzylpyrrolidin-3-ol
Brand: MedChemExpress
SKU: HY-W016644
Rating: 4.5 (1 reviews)

Cat. No.: HY-W016644 Purity: 99.64%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

(S)-1-Benzylpyrrolidin-3-ol (Compound 14) can be used to synthesis impurities of the anti-hypertensive agent Barnidipine hydrochloride (HY-107322).

For research use only. We do not sell to patients.

(S)-1-Benzylpyrrolidin-3-ol Chemical Structure

CAS No. : 101385-90-4

Size	Price	Stock	Quantity
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
1 g	USD 60	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

(S)-1-Benzylpyrrolidin-3-ol (Compound 14) can be used to synthesis impurities of the anti-hypertensive agent Barnidipine hydrochloride (HY-107322)^[1].

Molecular Weight

177.25

Formula

C₁₁H₁₅NO

CAS No.

101385-90-4

Appearance

Liquid

SMILES

O[C@@H]1CN(CC2=CC=CC=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (1410.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.6417 mL	28.2087 mL	56.4175 mL
5 mM	1.1283 mL	5.6417 mL	11.2835 mL
10 mM	0.5642 mL	2.8209 mL	5.6417 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (11.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (11.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (11.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.64%

Select Batch:

Data Sheet (271 KB) SDS (0 KB)

COA (247 KB) HNMR (124 KB) GC (189 KB)

Handling Instructions (2659 KB)

References

[1]. Cheng ZG, et al . Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance. Molecules. 2014 Jan 21;19(1):1344-52. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.6417 mL	28.2087 mL	56.4175 mL	141.0437 mL
	5 mM	1.1283 mL	5.6417 mL	11.2835 mL	28.2087 mL
	10 mM	0.5642 mL	2.8209 mL	5.6417 mL	14.1044 mL
	15 mM	0.3761 mL	1.8806 mL	3.7612 mL	9.4029 mL
	20 mM	0.2821 mL	1.4104 mL	2.8209 mL	7.0522 mL
	25 mM	0.2257 mL	1.1283 mL	2.2567 mL	5.6417 mL
	30 mM	0.1881 mL	0.9403 mL	1.8806 mL	4.7015 mL
	40 mM	0.1410 mL	0.7052 mL	1.4104 mL	3.5261 mL
	50 mM	0.1128 mL	0.5642 mL	1.1283 mL	2.8209 mL
	60 mM	0.0940 mL	0.4701 mL	0.9403 mL	2.3507 mL
	80 mM	0.0705 mL	0.3526 mL	0.7052 mL	1.7630 mL
	100 mM	0.0564 mL	0.2821 mL	0.5642 mL	1.4104 mL