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  4. (S)-2-Aminohexanedioic acid

(S)-2-Aminohexanedioic acid 

Cat. No.: HY-W013665 Purity: ≥97.0%
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(S)-2-Aminohexanedioic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

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(S)-2-Aminohexanedioic acid Chemical Structure

(S)-2-Aminohexanedioic acid Chemical Structure

CAS No. : 1118-90-7

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Based on 1 publication(s) in Google Scholar

(S)-2-Aminohexanedioic acid Related Antibodies

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Description

(S)-2-Aminohexanedioic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

In Vitro

Ki value of 209 μML-α-Aminoadipic Acid is a glutamine synthetase inhibitor. Glutamine synthetase is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine.In vitro: Previous study found that DL-and L-alpha-aminoadipic acid (alpha-AA) were specific gliotoxins in vitro. HPLC analysis of cultures incubated with D-or L-alpha-AA and DL-[14C]-alpha-AA autoradiograms conducted in the presence of D-or L-alpha-AA suggested a stereospecificity of astroglial L-alpha-AA uptake. Both the uptake of alpha-AA by astrocytes and alpha-AA-induced gliotoxicity were sodium dependent. Another study found that the L-isomer of alpha aminoadipate was able to competitively inhibit the transport protein, whereas the D-isomer of alpha aminoadipate was ineffective. Moreover, it was found that L-alpha aminoadipate was a competitive inhibitor of both glutamine synthetase, and gamma-glutam ylcysteine synthetase. In Constrast, the D-isomer of alpha aminoadipate was a far weaker inhibitor of either enzyme.In vivo: Animal study showed that La-aminoadipic acid could lower the levels of endogenous extracellular kynurenic acid in the hippocampus in a dose-dep endent fashion ), though the effect of La-aminoadipic acid seemed to be less pronounced than its reduction of de novo produced kynurenic acid . Clinical trial: So far, no clinical study has been conducted. References: Huck, S. ,Grass, F., and Hrtnagl, H. The glutamate analogue α-aminoadipic acid is taken up by astrocytes before exerting its gliotoxic effect in vitro. Journal of Neuroscience 4(10), 2650-2657 (1984). McBean GJ. Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, alpha aminoadipate. Br J Pharmacol. 1994 Oct;113(2):536-40. Wu HQ, Ungerstedt U, Schwarcz R. L-alpha-aminoadipic acid as a regulator of kynurenic acid production in the hippocampus: a microdialysis study in freely moving rats. Eur J Pharmacol. 1995 Jul 25;281(1):55-61.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-2-Aminohexanedioic acid Related Antibodies
Molecular Weight

161.16

Formula

C6H11NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](N)CCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1M HCl : 50 mg/mL (310.25 mM; ultrasonic and adjust pH to 1 with HCl)

DMSO : 10 mg/mL (62.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.2050 mL 31.0251 mL 62.0501 mL
5 mM 1.2410 mL 6.2050 mL 12.4100 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

COA (245 KB) HNMR (154 KB) MS (68 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 1M HCl 1 mM 6.2050 mL 31.0251 mL 62.0501 mL 155.1253 mL
5 mM 1.2410 mL 6.2050 mL 12.4100 mL 31.0251 mL
10 mM 0.6205 mL 3.1025 mL 6.2050 mL 15.5125 mL
15 mM 0.4137 mL 2.0683 mL 4.1367 mL 10.3417 mL
20 mM 0.3103 mL 1.5513 mL 3.1025 mL 7.7563 mL
25 mM 0.2482 mL 1.2410 mL 2.4820 mL 6.2050 mL
30 mM 0.2068 mL 1.0342 mL 2.0683 mL 5.1708 mL
40 mM 0.1551 mL 0.7756 mL 1.5513 mL 3.8781 mL
50 mM 0.1241 mL 0.6205 mL 1.2410 mL 3.1025 mL
60 mM 0.1034 mL 0.5171 mL 1.0342 mL 2.5854 mL
1M HCl 80 mM 0.0776 mL 0.3878 mL 0.7756 mL 1.9391 mL
100 mM 0.0621 mL 0.3103 mL 0.6205 mL 1.5513 mL
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(S)-2-Aminohexanedioic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-2-Aminohexanedioic acid1118-90-7Biochemical Assay Reagentsbiochemical reagentbiological materialorganic compoundlife scienceInhibitorinhibitorinhibit

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